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IPR003094 is a Fructose-2,6-bisphosphatase.
<p>6-Phosphofructo-2-kinase ([ec:2.7.1.105], [ec:3.1.3.46]) is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2, 6-bisphosphate. The fructose-2,6-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is: <reaction> ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate </reaction> <reaction> D-fructose 2,6-bisphosphate + H<sub>2</sub>O = 6-fructose 6-phosphate + P<sub>i</sub> </reaction> The enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver, kidney and heart. In mammals, several genes often encode different isoforms, each of which differs in its tissue distribution and enzymatic activity [[cite:PUB00001475]]. The family described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little sequence similarity, although a few residues seem key to their interaction with fructose 6-phosphate [[cite:PUB00000264]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Fructose 2,6-bisphosphate metabolic process | The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-like [Cicer arietinum] gi|502129390|ref|XP_004500284.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 14 | ||
| – | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase [Medicago truncatula] gi|357490933|ref|XP_003615754.1| | 10 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like [Glycine max] gi|356553092|ref|XP_003544892.1| | 20 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|K7M821|K7M821_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0117500 | 25 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|A0A0R0EWU2|A0A0R0EWU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 17 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|A0A151RYA5|A0A151RYA5_CAJCA 6PF-2-K/Fru-2,6-P2ASE liver isozyme; Found in the gene: LotjaGi6g1v0115600 | 14 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |