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IPR013079 is a 6-phosphofructo-2-kinase.
<p>6-Phosphofructo-2-kinase ([ec:2.7.1.105], [ec:3.1.3.46]) is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2, 6-bisphosphate. The fructose-2,6-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is: <reaction> ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate </reaction> <reaction> D-fructose 2,6-bisphosphate + H<sub>2</sub>O = 6-fructose 6-phosphate + P<sub>i</sub> </reaction> The enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver, kidney and heart. In mammals, several genes often encode different isoforms, each of which differs in its tissue distribution and enzymatic activity [[cite:PUB00001475]]. The family described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little sequence similarity, although a few residues seem key to their interaction with fructose 6-phosphate [[cite:PUB00000264]].</p> <p>This domain forms the N-terminal region of this enzyme, while [interpro:IPR013078] forms the C-terminal domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Fructose metabolic process | The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-like [Cicer arietinum] gi|502129390|ref|XP_004500284.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 14 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like [Glycine max] gi|356553092|ref|XP_003544892.1| | 20 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|K7M821|K7M821_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0117500 | 25 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|A0A0R0EWU2|A0A0R0EWU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 17 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |