Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR001345 is a Phosphoglycerate/bisphosphoglycerate mutase, active site.
<p>Phosphoglycerate mutase ([ec:5.4.2.1]) (PGAM) and bisphosphoglycerate mutase ([ec:5.4.2.4]) (BPGM) are structurally related enzymes that catalyse reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate [[cite:PUB00000183], [cite:PUB00001554], [cite:PUB00007922]]. Both enzymes can catalyse three different reactions with different specificities, the isomerization of 2-phosphoglycerate (2-PGA) to 3-phosphoglycerate (3-PGA) with 2,3-diphosphoglycerate (2,3-DPG) as the primer of the reaction, the synthesis of 2,3-DPG from 1,3-DPG with 3-PGA as a primer and the degradation of 2,3-DPG to 3-PGA (phosphatase [ec:3.1.3.13] activity).</p> <p>In mammals, PGAM is a dimeric protein with two isoforms, the M (muscle) and B (brain) forms. In yeast, PGAM is a tetrameric protein.</p> <p>BPGM is a dimeric protein and is found mainly in erythrocytes where it plays a major role in regulating haemoglobin oxygen affinity as a consequence of controlling 2,3-DPG concentration. The catalytic mechanism of both PGAM and BPGM involves the formation of a phosphohistidine intermediate [[cite:PUB00003558]].</p> <p>A number of other proteins including, the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [[cite:PUB00004695]] that catalyses both the synthesis and the degradation of fructose-2,6-bisphosphate and bacterial alpha-ribazole-5'-phosphate phosphatase, which is involved in cobalamin biosynthesis, belong to this family [[cite:PUB00002873]].</p> <p>This entry contains the active site phosphohistidine residue.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-like [Cicer arietinum] gi|502129390|ref|XP_004500284.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 18 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-like [Glycine max] gi|356569515|ref|XP_003552945.1| | 14 | ||
| – | PREDICTED: probable phosphoglycerate mutase GpmB-like [Cicer arietinum] gi|502152940|ref|XP_004509162.1| | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [Medicago truncatula] gi|357518595|ref|XP_003629586.1| | 11 | ||
| – | PREDICTED: probable phosphoglycerate mutase gpmB-like [Glycine max] gi|356514015|ref|XP_003525703.1| | 11 | ||
| – | PREDICTED: transcription factor MYB21-like [Glycine max] gi|356534359|ref|XP_003535723.1| | 14 | ||
| – | PREDICTED: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase-like [Glycine max] gi|356508122|ref|XP_003522809.1| | 14 | ||
| – | PREDICTED: broad-range acid phosphatase DET1-like [Cicer arietinum] gi|502117247|ref|XP_004495754.1| | 12 | ||
| – | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase [Medicago truncatula] gi|357481571|ref|XP_003611071.1| | 17 | ||
| – | PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like [Glycine max] gi|356553092|ref|XP_003544892.1| | 20 | ||
| – | 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase [Phaseolus vulgaris] gi|353227769|emb|CCE25834.1| | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [Medicago truncatula] gi|357471937|ref|XP_003606253.1| | 11 | ||
| – | PREDICTED: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase-like [Glycine max] gi|356511107|ref|XP_003524271.1| | 13 | ||
| – | PREDICTED: broad-range acid phosphatase DET1-like [Cicer arietinum] gi|502117247|ref|XP_004495754.1| | 11 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|K7M821|K7M821_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0117500 | 25 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G22170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q6MEW4|GPMA_PARUW 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TrEMBL-Plants: tr|I1JVH1|I1JVH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0147800 | 13 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G22170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q6MEW4|GPMA_PARUW 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TrEMBL-Plants: tr|I1JVH1|I1JVH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0147800 | 14 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G22170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q6MEW4|GPMA_PARUW 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A072UYQ0|A0A072UYQ0_MEDTR Phosphoglycerate/bisphosphoglycerate mutase family protein; Found in the gene: LotjaGi1g1v0245800 | 14 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G22170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q6MEW4|GPMA_PARUW 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TrEMBL-Plants: tr|I1JVH1|I1JVH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0245800 | 14 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT3G05170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q9MAA2|AT74_ARATH Phosphoglycerate mutase-like protein AT74; TrEMBL-Plants: tr|I3STP2|I3STP2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0435400 | 17 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT5G22620.1 phosphoglycerate/bisphosphoglycerate mutase family protein; Swiss-Prot: sp|Q9FNJ9|CA1P_ARATH Probable 2-carboxy-D-arabinitol-1-phosphatase; TrEMBL-Plants: tr|G7JKZ0|G7JKZ0_MEDTR 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase; Found in the gene: LotjaGi3g1v0480200 | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT3G50520.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q9SCS3|PGML4_ARATH Phosphoglycerate mutase-like protein 4; TrEMBL-Plants: tr|I3SA43|I3SA43_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0107500 | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT3G50520.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q9SCS3|PGML4_ARATH Phosphoglycerate mutase-like protein 4; TrEMBL-Plants: tr|I3T1R3|I3T1R3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0107600 | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G22170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q6MEW4|GPMA_PARUW 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TrEMBL-Plants: tr|V7CND9|V7CND9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0399800 | 13 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT3G05170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q9MAA2|AT74_ARATH Phosphoglycerate mutase-like protein AT74; TrEMBL-Plants: tr|G7I7H1|G7I7H1_MEDTR Phosphoglycerate/bisphosphoglycerate mutase family protein; Found in the gene: LotjaGi5g1v0218300 | 11 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT3G05170.1 Phosphoglycerate mutase family protein; Swiss-Prot: sp|Q9MAA2|AT74_ARATH Phosphoglycerate mutase-like protein AT74; TrEMBL-Plants: tr|G7I7H1|G7I7H1_MEDTR Phosphoglycerate/bisphosphoglycerate mutase family protein; Found in the gene: LotjaGi5g1v0218300 | 12 | ||
| – | Myb transcription factor; TAIR: AT1G68320.1 myb domain protein 62; Swiss-Prot: sp|Q9C9G7|MYB62_ARATH Transcription factor MYB62; TrEMBL-Plants: tr|G7ICA5|G7ICA5_MEDTR Myb transcription factor; Found in the gene: LotjaGi5g1v0338500 | 14 | ||
| – | Myb transcription factor; TAIR: AT1G68320.1 myb domain protein 62; Swiss-Prot: sp|Q9C9G7|MYB62_ARATH Transcription factor MYB62; TrEMBL-Plants: tr|V7BAR9|V7BAR9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0338900 | 14 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|A0A0R0EWU2|A0A0R0EWU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 17 | ||
| – | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|A0A151RYA5|A0A151RYA5_CAJCA 6PF-2-K/Fru-2,6-P2ASE liver isozyme; Found in the gene: LotjaGi6g1v0115600 | 14 | ||
| – | 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; TAIR: AT1G07110.1 fructose-2,6-bisphosphatase; Swiss-Prot: sp|Q9MB58|F26_ARATH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; TrEMBL-Plants: tr|I1LLN3|I1LLN3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0115600 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 2.94 |