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IPR003557 is a Cytochrome c-type biogenesis protein CcmC.
<p>Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [[cite:PUB00002276]], CcmF [[cite:PUB00002274], [cite:PUB00003599]], NrfE [[cite:PUB00006649]] and CcbS [[cite:PUB00006642]]. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase. Members of the family are probably integral membrane proteins, with up to 16 predicted transmembrane (TM) helices.</p> <p>The gene products of the hel and ccl loci have been shown to be required specifically for the biogenesis of c-type cytochromes in the Gram-negative photosynthetic bacterium Rhodobacter capsulatus [[cite:PUB00006638]]. Genetic and molecular analyses show that the hel locus contains at least 4 genes, helA, helB, helC and orf52. HelA is similar to the ABC transporters and helA, helB, and helC are proposed to encode an export complex [[cite:PUB00006649]]. It is believed that the hel-encoded proteins are required for the export of haem to the periplasm, where it is subsequently ligated to the c-type apocytochromes [[cite:PUB00006638]]. However, while CcmB and CcmC have the potential to interact with CcmA, the 3 gene products probably associating to form a complex with (CcmA)2-CcmB-CcmC stoichiometry, the substrate for the putative CcmABC-transporter is probably neither haem nor c-type apocytochromes [[cite:PUB00003599]]. Hydropathy analysis suggests the presence of 6 TM domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Heme transporter activity | Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells. | ||
| Biological process | Heme transport | The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ||
| Biological process | Cytochrome complex assembly | The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cytochrome c biogenesis C (mitochondrion) [Glycine max] gi|476507671|ref|YP_007516851.1| | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 100.00 |