Description

IPR003595 is a Protein-tyrosine phosphatase, catalytic.

<p>This entry represents the PTP-signature motif that characterises the catalytic site, and which encompasses only part of the PTPase domain structure.</p> <p>Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; [ec:3.1.3.48]) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [[cite:PUB00035793], [cite:PUB00035794]]. The PTP superfamily can be divided into four subfamilies [[cite:PUB00035795]]:</p> <ul> <li>(1) pTyr-specific phosphatases</li> <li>(2) dual specificity phosphatases (dTyr and dSer/dThr)</li> <li>(3) Cdc25 phosphatases (dTyr and/or dThr)</li> <li>(4) LMW (low molecular weight) phosphatases</li> </ul> <p>Based on their cellular localisation, PTPases are also classified as:</p> <ul> <li>Receptor-like, which are transmembrane receptors that contain PTPase domains [[cite:PUB00035796]]</li> <li>Non-receptor (intracellular) PTPases [[cite:PUB00035797]]</li> </ul> <p>All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel β-sheet with flanking α-helices containing a β-loop-α-loop that encompasses the PTP signature motif [[cite:PUB00035798]]. Functional diversity between PTPases is endowed by regulatory domains and subunits.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: