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IPR003700 is a Ketopantoate hydroxymethyltransferase.
<p>The panB gene from Escherichia coli encodes the first enzyme of the pantothenate biosynthesis pathway, ketopantoate hydroxymethyltransferase (KPHMT) [ec:2.1.2.11]. Fungal ketopantoate hydroxymethyltransferase is essential for the biosynthesis of coenzyme A, while the pathway intermediate 4'-phosphopantetheine is required for penicillin production [[cite:PUB00008182]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. | ||
| Biological process | Pantothenate biosynthetic process | The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase [Medicago truncatula] gi|357504415|ref|XP_003622496.1| | 10 | ||
| – | PREDICTED: 3-methyl-2-oxobutanoate hydroxymethyltransferase-like [Glycine max] gi|356522560|ref|XP_003529914.1| | 8 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|I1KI28|I1KI28_SOYBN 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0315000 | 10 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0315000 | 10 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0315000 | 10 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A178VE54|A0A178VE54_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0315000 | 7 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A178VE54|A0A178VE54_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi1g1v0315000 | 7 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi5g1v0035000 | 11 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi5g1v0035000 | 11 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi5g1v0035000 | 11 | ||
| – | 3-methyl-2-oxobutanoate hydroxymethyltransferase; TAIR: AT3G61530.1 Phosphoenolpyruvate carboxylase family protein; Swiss-Prot: sp|Q9M315|PANB2_ARATH 3-methyl-2-oxobutanoate hydroxymethyltransferase 2, mitochondrial; TrEMBL-Plants: tr|A0A072TNM1|A0A072TNM1_MEDTR 3-methyl-2-oxobutanoate hydroxymethyltransferase; Found in the gene: LotjaGi6g1v0291700_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51621 | SUPERFAMILY | 1 | 9.09 |