Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003769 is a Adaptor protein ClpS, core.
<p>In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [[cite:PUB00013965]].</p> <p>ClpS is a small alpha/beta protein that consists of three α-helices connected to three antiparallel β-strands [[cite:PUB00013966]]. The protein has a globular shape, with a curved layer of three antiparallel α-helices over a twisted antiparallel β-sheet. Dimerization of ClpS may occur through its N-terminal domain. This short extended N-terminal region in ClpS is followed by the central seven-residue β-strand, which is flanked by two other β-strands in a small β-sheet.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ATP-dependent Clp protease adapter protein clpS [Medicago truncatula] gi|357488429|ref|XP_003614502.1| | 7 | ||
| – | PREDICTED: ATP-dependent Clp protease adapter protein ClpS-like [Glycine max] gi|356531226|ref|XP_003534179.1| | 12 | ||
| – | ATP-dependent Clp protease adapter protein clpS [Medicago truncatula] gi|357488429|ref|XP_003614502.1| | 7 | ||
| – | ATP-dependent Clp protease adapter protein clpS; TAIR: AT1G68660.1 Ribosomal protein L12/ ATP-dependent Clp protease adaptor protein ClpS family protein; Swiss-Prot: sp|Q9SX29|CLPS1_ARATH ATP-dependent Clp protease adapter protein CLPS1, chloroplastic; TrEMBL-Plants: tr|I3SN73|I3SN73_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0211800 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54736 | SUPERFAMILY | 1 | 25.00 |