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IPR004344 is a Tubulin-tyrosine ligase/Tubulin polyglutamylase.
<p>Tubulins and microtubules are subjected to several post-translational modifications of the carboxy-terminal end of most major forms of tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL) and the tubulin polyglutamylase (TTLL) [[cite:PUB00007535], [cite:PUB00066571]]. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. Tubulin polyglutamylase (such as TTLL10) can modify both tubulin and non-tubulin proteins, generating side chains of glycine on the γ-carboxyl groups of specific glutamate residues of target proteins [[cite:PUB00066571]]. Tubulin polyglutamylation may be involved in the organisation of the neuronal microtubule network, in centriole stability, axoneme motility and mitosis [[cite:PUB00066565]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tubulin--tyrosine ligase-like protein 12-like isoform 1 [Glycine max] gi|356556388|ref|XP_003546508.1| | 7 | ||
| – | PREDICTED: tubulin--tyrosine ligase-like protein 12-like isoform 1 [Glycine max] gi|356556388|ref|XP_003546508.1| | 9 | ||
| – | Tubulin-tyrosine ligase family protein; TAIR: AT1G77550.1 tubulin-tyrosine ligase; Swiss-Prot: sp|Q3UDE2|TTL12_MOUSE Tubulin--tyrosine ligase-like protein 12; TrEMBL-Plants: tr|A0A151RWF2|A0A151RWF2_CAJCA Tubulin--tyrosine ligase-like protein 12; Found in the gene: LotjaGi6g1v0225000 | 12 | ||
| – | Tubulin-tyrosine ligase family protein; TAIR: AT1G77550.1 tubulin-tyrosine ligase; Swiss-Prot: sp|Q3UDE2|TTL12_MOUSE Tubulin--tyrosine ligase-like protein 12; TrEMBL-Plants: tr|A0A151RWF2|A0A151RWF2_CAJCA Tubulin--tyrosine ligase-like protein 12; Found in the gene: LotjaGi6g1v0225000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56059 | SUPERFAMILY | 1 | 25.00 |