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IPR004374 is a Peptide chain release factor 2.
<p>Peptide chain release factors (RFs) are required for the termination of protein biosynthesis [[cite:PUB00004944]]. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner [[cite:PUB00003804]]: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB), which is represented by this entry, mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown [[cite:PUB00004407]] to be part of a larger family.</p> <p>This entry represents peptide chain release factor 2 (PrfB, RF-2). It also includes chloroplastic release factor PrfB, which is required for the proper translation and stability of UGA-containing transcripts in chloroplasts [[cite:PUB00085742]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Translational termination | The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). | ||
| Molecular function | Translation release factor activity, codon specific | A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peptide chain release factor 2-like [Glycine max] gi|356571075|ref|XP_003553706.1| | 9 | ||
| – | PREDICTED: peptide chain release factor 2-like [Glycine max] gi|356531868|ref|XP_003534498.1| | 16 | ||
| – | PREDICTED: peptide chain release factor 2-like [Glycine max] gi|356571075|ref|XP_003553706.1| | 16 | ||
| – | Peptide chain release factor, putative; TAIR: AT5G36170.1 high chlorophyll fluorescent 109; Swiss-Prot: sp|Q9LVY0|PRFB1_ARATH Peptide chain release factor PrfB1, chloroplastic; TrEMBL-Plants: tr|I1L681|I1L681_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0487600 | 16 | ||
| – | Peptide chain release factor, putative; TAIR: AT1G56350.1 Peptide chain release factor 2; Swiss-Prot: sp|F4I532|PRFB2_ARATH Peptide chain release factor PrfB2, chloroplastic; TrEMBL-Plants: tr|V7D0Y9|V7D0Y9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0748100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00020 | TIGRFAM | 1 | 20.00 |