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IPR004393 is a Nicotinate-nucleotide pyrophosphorylase.
<p>Nicotinate-nucleotide pyrophosphorylase ([ec:2.4.2.19]), also known as quinolinate phosphoribosyltransferase (decarboxylating), catalyses the conversion of nicotinate D-ribonucleotide, pyrophosphate and carbon dioxide into pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate. This enzyme is a type II phosphoribosyltransferase which provides the<i>de novo</i>source of nicotinate mononucleotide (NAMN) for NAD biosynthesis in both prokaryotes and eukaryotes [[cite:PUB00017199], [cite:PUB00017200]].</p> <p>Structural studies have shown that the active form of this enzyme is a homodimer with an unsual fold [[cite:PUB00005289], [cite:PUB00017201], [cite:PUB00017204]]. The N-terminal forms a mixed α/β domain, while the C-terminal region forms a multi-stranded, open α/β-barrel. The active site is found at the C-terminal ends of the β-strands of the α/β-barrel, and is bordered by the N-terminal domain of the second subunit of the dimer. It contains several conserved charged residues thought to be important determinants of substrate binding and catalysis.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nicotinate-nucleotide diphosphorylase (carboxylating) activity | Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. | ||
| Biological process | NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A072VQY4|A0A072VQY4_MEDTR Quinolinate phosphoribosyltransferase, putative; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2RX79|A0A0B2RX79_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 19 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2RX79|A0A0B2RX79_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 17 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01572 | CDD | 1 | 16.67 |