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IPR027277 is a Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD.
<p>Proteins in this family includes nicotinate-nucleotide pyrophosphorylase ([ec:2.4.2.19], also known as quinolinate phosphoribosyl transferases) and putative pyrophosphorylase ModD.</p> <p>Nicotinate-nucleotide pyrophosphorylase is a type II phosphoribosyltransferase which provides the <i>de novo</i> source of nicotinate mononucleotide (NAMN) for NAD biosynthesis in both prokaryotes and eukaryotes [[cite:PUB00017199], [cite:PUB00017200]]. Human quinolinate phosphoribosyltransferase (also known as hQPRTase) is involved in the catabolism of quinolinic acid (QA) [[cite:PUB00047847], [cite:PUB00101112]]. Elevation of QA levels in the brain has been linked to the pathogenesis of a range of neurodegenerative disorders [[cite:PUB00063666]].</p> <p>ModD is found with molybdenum transport genes modABC in Rhodobacter capsulatus. However, disruption of modD causes only a 4-fold (rather than 500-fold for modA, modB, modC) change in the external molybdenum concentration required to suppress an alternative nitrogenase [[cite:PUB00009574]]. ModD proteins are highly similar to nicotinate-nucleotide pyrophosphorylase (also called quinolinate phosphoribosyltransferase). Their function is unknown.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A072VQY4|A0A072VQY4_MEDTR Quinolinate phosphoribosyltransferase, putative; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2RX79|A0A0B2RX79_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 19 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2RX79|A0A0B2RX79_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 18 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 17 | ||
| – | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; TAIR: AT2G01350.1 quinolinate phoshoribosyltransferase; Swiss-Prot: sp|Q9ZU32|NADC_ARATH Nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic; TrEMBL-Plants: tr|A0A0B2S2R6|A0A0B2S2R6_GLYSO Putative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Found in the gene: LotjaGi2g1v0061600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01572 | CDD | 1 | 16.67 |