Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR004404 is a Dihydroxy-acid dehydratase.
<p>Two dehydratases, dihydroxy-acid dehydratase (gene ilvD or ILV3) and 6-phosphogluconate dehydratase (gene edd) have been shown to be evolutionary related [[cite:PUB00002191]]. Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6-Phosphogluconate dehydratase catalyzes the first step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho-D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. Another protein containing this signature is the Escherichia coli hypothetical protein yjhG. The N-terminal part of the proteins contains a cysteine that could be involved in the binding of a 2Fe-2S iron-sulphur cluster [[cite:PUB00001841]].</p> <p>This family represents dihydroxy-acid dehydratase (DAD). It contains a catalytically essential [4Fe-4S] cluster and catalyses the fourth step in valine and isoleucine biosynthesis.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Dihydroxy-acid dehydratase activity | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. | ||
| Biological process | Branched-chain amino acid biosynthetic process | The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydroxy-acid dehydratase-like [Glycine max] gi|356548991|ref|XP_003542882.1| | 13 | ||
| – | Dihydroxy-acid dehydratase; TAIR: AT3G23940.1 dehydratase family; Swiss-Prot: sp|Q9LIR4|ILVD_ARATH Dihydroxy-acid dehydratase, chloroplastic; TrEMBL-Plants: tr|I1M137|I1M137_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0297500 | 15 | ||
| – | Dihydroxy-acid dehydratase; TAIR: AT3G23940.1 dehydratase family; Swiss-Prot: sp|Q9LIR4|ILVD_ARATH Dihydroxy-acid dehydratase, chloroplastic; TrEMBL-Plants: tr|I1M137|I1M137_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0297500 | 13 | ||
| – | Dihydroxy-acid dehydratase; TAIR: AT3G23940.1 dehydratase family; Swiss-Prot: sp|Q9LIR4|ILVD_ARATH Dihydroxy-acid dehydratase, chloroplastic; TrEMBL-Plants: tr|I1M137|I1M137_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0297500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00110 | TIGRFAM | 1 | 25.00 |