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IPR004472 is a Dethiobiotin synthase BioD.
<p>BioD is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP) [[cite:PUB00056787]]. It binds ATP and requires magnesium as a co-factor.</p> <p>Proteins in this entry also include bifunctional proteins, such as BioCD from Bordetella avium, BioDA from Aspergillus nidulans [[cite:PUB00093987]], and BIO3-BIO1 protein from plants. They are also involved in the biotin biosynthesis [[cite:PUB00085095]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. | ||
| Molecular function | Dethiobiotin synthase activity | Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Biotin biosynthetic process | The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: l-Lysine-8-amino-7-oxononanoate aminotransferase-like [Glycine max] gi|356550752|ref|XP_003543748.1| | 18 | ||
| – | Aminotransferase; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 19 | ||
| – | ATP-dependent dethiobiotin synthetase BioD; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|K7LWW0|K7LWW0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 16 | ||
| – | Glutamate-1-semialdehyde-2,1-aminomutase; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 19 | ||
| – | Aminotransferase; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 19 | ||
| – | Aminotransferase; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 19 | ||
| – | ATP-dependent dethiobiotin synthetase BioD; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 16 | ||
| – | ATP-dependent dethiobiotin synthetase BioD; TAIR: AT5G57590.1 adenosylmethionine-8-amino-7-oxononanoate transaminase; Swiss-Prot: sp|B0F481|BIODA_ARATH Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial; TrEMBL-Plants: tr|I1LVT1|I1LVT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0298400 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03109 | CDD | 1 | 12.50 |