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IPR004508 is a Thioredoxin-independent 5'-adenylylsulphate reductase.
<p>This enzyme, involved in the assimilation of inorganic sulphate, is closely related to the thioredoxin-dependent PAPS reductase of Bacteria (CysH) and Saccharomyces cerevisiae. However, it has its own C-terminal thioredoxin-like domain and is not thioredoxin-dependent. Also, it has a substrate preference for 5'-adenylylsulphate (APS) over 3'-phosphoadenylylsulphate (PAPS) so the pathway does not require an APS kinase (CysC) to convert APS to PAPS. Arabidopsis thaliana appears to have three isozymes, all able to complement Escherichia coli CysH mutants (even in backgrounds lacking thioredoxin or APS kinase) but likely localized to different compartments in Arabidopsis.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. | ||
| Biological process | Sulfate reduction | The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 5'-adenylylsulfate reductase 3, chloroplastic-like [Glycine max] gi|356521997|ref|XP_003529636.1| | 24 | ||
| – | PREDICTED: 5'-adenylylsulfate reductase 1, chloroplastic-like [Cicer arietinum] gi|502079145|ref|XP_004486168.1| | 18 | ||
| – | 5'-adenylylsulfate reductase; TAIR: AT4G21990.1 APS reductase 3; Swiss-Prot: sp|P92980|APR3_ARATH 5'-adenylylsulfate reductase 3, chloroplastic; TrEMBL-Plants: tr|I3S182|I3S182_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0013600 | 20 | ||
| – | 5'-adenylylsulfate reductase; TAIR: AT4G21990.1 APS reductase 3; Swiss-Prot: sp|P92980|APR3_ARATH 5'-adenylylsulfate reductase 3, chloroplastic; TrEMBL-Plants: tr|A0A072V4H5|A0A072V4H5_MEDTR 5'-adenylylsulfate reductase; Found in the gene: LotjaGi6g1v0294100 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |