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IPR004557

Source: InterPro

Description

IPR004557 is a Eukaryotic/archaeal PrmC-related.

<p>These proteins exhibit homology to the Saccharomyces cerevisiae Mtq2 (also know as PrmC [[cite:PUB00090823]]). Mtq2 methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated [[cite:PUB00063061], [cite:PUB00063062], [cite:PUB00041889]]. In bacteria, the methylation of RF1/RF2 by PrmC is important for normal growth, to increase the affinity of RF1/RF2 for ribosomes and to enhance translation termination [[cite:PUB00093695], [cite:PUB00093696]]. Human homologue of Mtq2 is called hemK methyltransferase family member 2 (HEMK2, also known as N6AMT1), which is an N6-adenine-specific DNA methyltransferase [[cite:PUB00090976]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0435400.1
– Methyltransferase; TAIR: AT3G13440.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9Y5N5|HEMK2_HUMAN HemK methyltransferase family member 2; TrEMBL-Plants: tr|Q2HS71|Q2HS71_MEDTR SAM (And some other nucleotide) binding motif; Methyltransferase small; Tetratricopeptide-like helical; Found in the gene: LotjaGi3g1v0435400
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02440 CDD 1 100.00