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IPR002052 is a DNA methylase, N-6 adenine-specific, conserved site.
<p>In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. There are 2 major classes of DNA methyltransferase that differ in the nature of the modifications they effect. The members of one class (C-MTases) methylate a ring carbon and form C5-methylcytosine (see PRINTS signature C5METTRFRASE). Members of the second class (N-MTases) methylate exocyclic nitrogens and form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases). Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM) as the methyl donor and are active as monomeric enzymes [[cite:PUB00000092]].</p> <p>N-6 adenine-specific DNA methylases ([ec:2.1.1.72]) (A-Mtase) are enzymes that specifically methylate the amino group at the C-6 position of adenines in DNA. Such enzymes are found in the three existing types of bacterial` restriction-modification systems (in type I system the A-Mtase is the product of the hsdM gene, and in type III it is the product of the mod gene). All of these enzymes recognise a specific sequence in DNA and methylate an adenine in that sequence. It has been shown [[cite:PUB00003225], [cite:PUB00001770], [cite:PUB00003245], [cite:PUB00001857]] that A-Mtases contain a conserved motif Asp/Asn-Pro-Pro-Tyr/Phe in their N-terminal section, this conserved region could be involved in substrate binding or in the catalytic activity.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. | ||
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. | ||
| Biological process | Methylation | The process in which a methyl group is covalently attached to a molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Acetoin dehydrogenase [Bacillus halodurans C]-125] gi|15615797|ref|NP_244101.1| | 2 | ||
| – | PREDICTED: protein methyltransferase hemK homolog [Glycine max] gi|356525752|ref|XP_003531487.1| | 12 | ||
| – | PREDICTED: N(6)-adenine-specific DNA methyltransferase 2-like [Cicer arietinum] gi|502141459|ref|XP_004504516.1| | 10 | ||
| – | PREDICTED: N(6)-adenine-specific DNA methyltransferase 2-like [Cicer arietinum] gi|502141459|ref|XP_004504516.1| | 8 | ||
| – | PREDICTED: methyltransferase-like protein 5-like [Cicer arietinum] gi|502163993|ref|XP_004513013.1| | 10 | ||
| – | PREDICTED: methyltransferase-like protein 5-like [Cicer arietinum] gi|502163993|ref|XP_004513013.1| | 6 | ||
| – | PREDICTED: protein methyltransferase hemK homolog [Glycine max] gi|356525752|ref|XP_003531487.1| | 12 | ||
| – | PREDICTED: tRNA guanosine-2'-O-methyltransferase TRM11 homolog [Glycine max] gi|356512097|ref|XP_003524757.1| | 12 | ||
| – | PREDICTED: methyltransferase-like protein 1-like isoform X1 [Cicer arietinum] gi|502119204|ref|XP_004496538.1| | 12 | ||
| – | Quinoprotein amine dehydrogenase, beta chain-like; RIC1-like guanyl-nucleotide exchange factor; TAIR: AT5G05490.1 Rad21/Rec8-like family protein; Swiss-Prot: sp|Q4FS42|MSBA_PSYA2 Lipid A export ATP-binding/permease protein MsbA; TrEMBL-Plants: tr|D7LYX7|D7LYX7_ARALL DIF1/SYN1; Found in the gene: LotjaGi1g1v0764800_LC | 6 | ||
| – | Ribosomal L11 methyltransferase; TAIR: AT4G28830.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q8K1A0|METL5_MOUSE Methyltransferase-like protein 5; TrEMBL-Plants: tr|I3SR90|I3SR90_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0220400 | 11 | ||
| – | Methyltransferase; TAIR: AT5G64150.1 RNA methyltransferase family protein; Swiss-Prot: sp|Q8DHV7|PRMC_THEEB Release factor glutamine methyltransferase; TrEMBL-Plants: tr|A0A0B2SVL3|A0A0B2SVL3_GLYSO Release factor glutamine methyltransferase; Found in the gene: LotjaGi3g1v0135500 | 12 | ||
| – | Methyltransferase; TAIR: AT3G13440.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9Y5N5|HEMK2_HUMAN HemK methyltransferase family member 2; TrEMBL-Plants: tr|Q2HS71|Q2HS71_MEDTR SAM (And some other nucleotide) binding motif; Methyltransferase small; Tetratricopeptide-like helical; Found in the gene: LotjaGi3g1v0435400 | 12 | ||
| – | TRNA (Guanine(10)-N2)-methyltransferase like; TAIR: AT3G26410.1 tRNA modification 11 protein; Swiss-Prot: sp|Q6NS23|TRM11_XENLA tRNA (guanine(10)-N2)-methyltransferase homolog; TrEMBL-Plants: tr|A0A0B2R4A8|A0A0B2R4A8_GLYSO tRNA (Guanine(10)-N2)-methyltransferase like; Found in the gene: LotjaGi4g1v0032100 | 12 | ||
| – | TRNA (Guanine(10)-N2)-methyltransferase like; TAIR: AT3G26410.1 tRNA modification 11 protein; Swiss-Prot: sp|Q6NS23|TRM11_XENLA tRNA (guanine(10)-N2)-methyltransferase homolog; TrEMBL-Plants: tr|I1K2S5|I1K2S5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0032100 | 12 | ||
| – | Quinoprotein amine dehydrogenase, beta chain-like; RIC1-like guanyl-nucleotide exchange factor; TAIR: AT5G05490.1 Rad21/Rec8-like family protein; Swiss-Prot: sp|Q4FS42|MSBA_PSYA2 Lipid A export ATP-binding/permease protein MsbA; TrEMBL-Plants: tr|D7LYX7|D7LYX7_ARALL DIF1/SYN1; Found in the gene: LotjaGi5g1v0048700_LC | 6 | ||
| – | Protein-lysine N-methyltransferase; TAIR: AT3G58470.1 nucleic acid binding / methyltransferase; Swiss-Prot: sp|Q9CY45|N6MT2_MOUSE Protein-lysine N-methyltransferase N6amt2; TrEMBL-Plants: tr|A0A0R0IGD8|A0A0R0IGD8_SOYBN Protein-lysine N-methyltransferase GLYMA_09G103300; Found in the gene: LotjaGi5g1v0112000 | 10 | ||
| – | Methyltransferase-like protein 1; TAIR: AT4G09980.1 Methyltransferase MT-A70 family protein; Swiss-Prot: sp|Q94AI4|METL1_ARATH Methyltransferase-like protein 1; TrEMBL-Plants: tr|I1NGX0|I1NGX0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0298100 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.56 |