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IPR004570 is a CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.
<p>CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase ([ec:2.7.8.5]), also known as phosphatidylglycerophosphate synthase, glycerophosphate phosphatidyltransferase and PGP synthase, catalyses the conversion of CDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the committed step to the synthesis of acidic phospholipids. It is an integral membrane protein. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharomyces cerevisiae (Baker's yeast) YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologues as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). | ||
| Biological process | Phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-like isoform X2 [Cicer arietinum] gi|502174686|ref|XP_004515577.1| | 17 | ||
| – | PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-like [Cicer arietinum] gi|502121566|ref|XP_004497372.1| | 16 | ||
| – | PREDICTED: cardiolipin synthase-like [Cicer arietinum] gi|502079005|ref|XP_004486123.1| | 9 | ||
| – | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TAIR: AT2G39290.1 phosphatidylglycerolphosphate synthase 1; Swiss-Prot: sp|O80952|PGPS1_ARATH CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1, chloroplastic; TrEMBL-Plants: tr|K7MVM8|K7MVM8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0466400 | 18 | ||
| – | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TAIR: AT2G39290.1 phosphatidylglycerolphosphate synthase 1; Swiss-Prot: sp|O80952|PGPS1_ARATH CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I3SDB6|I3SDB6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0361800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |