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IPR004607

Source: InterPro

Description

IPR004607 is a Phosphoribosylglycinamide formyltransferase.

<p>Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis [[cite:PUB00075622]]. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein [[cite:PUB00080573]] but in most eukaryotes GART (purN) resides in the C-terminal portion of a large multifunctional protein which also contains GAR synthetase (purD) and aminoimidazole ribonucleotide (AIR) synthetase (purM) activities [[cite:PUB00027303]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004644
Molecular function Phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
Subterm of
GO:0006189
Biological process 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0649600.1
– Methionyl-tRNA formyltransferase; TAIR: AT1G31220.1 Formyl transferase; Swiss-Prot: sp|P52423|PUR3_VIGUN Phosphoribosylglycinamide formyltransferase, chloroplastic; TrEMBL-Plants: tr|A0A0S3RWK0|A0A0S3RWK0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0649600
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd08645 CDD 1 100.00