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IPR036477 is a Formyl transferase, N-terminal domain superfamily.
<p>A number of formyl transferases belong to this group. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl minoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-ormylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. Formyltetrahydrofolate dehydrogenase produces formate from formyl-tetrahydrofolate. This is the N-terminal domain of these enzymes and is found upstream of the C-terminal domain ([interpro:IPR005793]).</p> <p>The trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase catalyses the second, third and fifth steps in de novo purine biosynthesis. The glycinamide ribonucleotide transformylase belongs to this group.</p> <p>The formyl transferase N-terminal domain structure has a three layers (α/β/α) fold, with a mixed β-sheet of seven strands where strand 6 is antiparallel to the rest.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Biosynthetic process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. | ||
| Molecular function | Hydroxymethyl-, formyl- and related transferase activity | Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Methionyl-tRNA formyltransferase; TAIR: AT1G31220.1 Formyl transferase; Swiss-Prot: sp|P52423|PUR3_VIGUN Phosphoribosylglycinamide formyltransferase, chloroplastic; TrEMBL-Plants: tr|A0A0S3RWK0|A0A0S3RWK0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0649600 | 12 | ||
| – | Methionyl-tRNA formyltransferase; TAIR: AT1G66520.1 formyltransferase; Swiss-Prot: sp|Q65JS5|FMT_BACLD Methionyl-tRNA formyltransferase; TrEMBL-Plants: tr|A0A0L9T444|A0A0L9T444_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0237200 | 24 | ||
| – | Methionyl-tRNA formyltransferase; TAIR: AT5G47435.1 formyltetrahydrofolate deformylase; Swiss-Prot: sp|Q93YQ3|PURU1_ARATH Formyltetrahydrofolate deformylase 1, mitochondrial; TrEMBL-Plants: tr|A0A0L9TQX6|A0A0L9TQX6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0202000 | 17 | ||
| – | Formyltetrahydrofolate deformylase; TAIR: AT5G47435.1 formyltetrahydrofolate deformylase; Swiss-Prot: sp|Q93YQ3|PURU1_ARATH Formyltetrahydrofolate deformylase 1, mitochondrial; TrEMBL-Plants: tr|K7KN51|K7KN51_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0202000 | 15 | ||
| – | Methionyl-tRNA formyltransferase; TAIR: AT5G47435.1 formyltetrahydrofolate deformylase; Swiss-Prot: sp|Q93YQ3|PURU1_ARATH Formyltetrahydrofolate deformylase 1, mitochondrial; TrEMBL-Plants: tr|A0A0L9TQX6|A0A0L9TQX6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0202000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04875 | CDD | 1 | 20.00 |