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IPR004730 is a Transaldolase type 1.
<p>Transaldolase ([ec:2.2.1.2]) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated [[cite:PUB00005649]] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.</p> <p>This entry represents trasnaldolase type 1, which is found in bacteria, metazoa and fungi. The enzyme is found in the non-oxidative branch of the pentose phosphate pathway and forms a dimer in solution [[cite:PUB00081753]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity | Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Pentose-phosphate shunt | The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transaldolase-like [Glycine max] gi|356514222|ref|XP_003525805.1| | 14 | ||
| – | Transaldolase; TAIR: AT1G12230.1 Aldolase superfamily protein; Swiss-Prot: sp|Q65PZ8|TAL_MANSM Transaldolase; TrEMBL-Plants: tr|I3TA48|I3TA48_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0208800 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00957 | CDD | 1 | 50.00 |