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IPR004769

Source: InterPro

Description

IPR004769 is a Adenylosuccinate lyase.

<p>This family consists of adenylosuccinate lyase, the enzyme that catalyses step 8 in the purine biosynthesis pathway for de novo synthesis of IMP, and also the final reaction in the two-step sequence from IMP to AMP [[cite:PUB00017611], [cite:PUB00151518]]. It is a member of lyase class I family, which functions as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits [[cite:PUB00023841]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004018
Molecular function N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
Subterm of
GO:0009152
Biological process Purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v4139420.1
– PREDICTED: adenylosuccinate lyase-like [Glycine max] gi|356501123|ref|XP_003519378.1|
Domains
19
LotjaGi1g1v0081500.1
– Adenylosuccinate lyase; TAIR: AT1G36280.1 L-Aspartase-like family protein; Swiss-Prot: sp|P44797|PUR8_HAEIN Adenylosuccinate lyase; TrEMBL-Plants: tr|V7B898|V7B898_PHAVU Adenylosuccinate lyase; Found in the gene: LotjaGi1g1v0081500
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01598 CDD 1 50.00