Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR004789 is a Acetolactate synthase, small subunit.
<p>Acetolactate synthases are a group of biosynthetic enzymes apparently found in plants, fungi and bacteria that are capable of<i>de novo</i>synthesis of the branched-chain amino acids [[cite:PUB00033863]]. They can all synthesize acetolactate from pyruvate in the biosynthesis of valine, while some are also capable of synthesizing acetohydroxybutyrate from pyruvate and ketobutyrate during the biosynthesis of isoleucine. These enzymes generally require thiamin diphosphate, FAD and a divalent metal ion for catalysis, though some enzymes specific for acetolactate synthesis do not require FAD. They are composed of two subunits, a large catalytic subunit, and a smaller regulatory subunit which binds the natural modulators (valine, and in some cases leucine or isoleucine).</p> <p>These enzymes are the target for currently-used herbicides such as sulphonylureas and imidazolinones. Their restricted distribution also makes them potential targets for the development of novel antibacterial and antifungal compounds.</p> <p>This entry represents the small regulatory subunit of acetolactate synthase. It contains an ACT domain, which is a predicted regulatory ligand-binding fold often found in proteins regulated by small-molecule effectors [[cite:PUB00007206]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Branched-chain amino acid biosynthetic process | The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. | ||
| Molecular function | Acetolactate synthase regulator activity | Binds to and modulates the activity of acetolactate synthase. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Acetolactate synthase small subunit [Medicago truncatula] gi|357519313|ref|XP_003629945.1| | 15 | ||
| – | PREDICTED: acetolactate synthase small subunit 2, chloroplastic-like isoform X2 [Cicer arietinum] gi|502093821|ref|XP_004490063.1| | 16 | ||
| – | Acetolactate synthase, small subunit; TAIR: AT2G31810.1 ACT domain-containing small subunit of acetolactate synthase protein; Swiss-Prot: sp|Q93YZ7|ILVH2_ARATH Acetolactate synthase small subunit 2, chloroplastic; TrEMBL-Plants: tr|I3SMD8|I3SMD8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0387300 | 16 | ||
| – | Acetolactate synthase small subunit; TAIR: AT2G31810.1 ACT domain-containing small subunit of acetolactate synthase protein; Swiss-Prot: sp|Q93YZ7|ILVH2_ARATH Acetolactate synthase small subunit 2, chloroplastic; TrEMBL-Plants: tr|I3SMD8|I3SMD8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0387300 | 16 | ||
| – | Acetolactate synthase, small subunit; TAIR: AT2G31810.1 ACT domain-containing small subunit of acetolactate synthase protein; Swiss-Prot: sp|Q93YZ7|ILVH2_ARATH Acetolactate synthase small subunit 2, chloroplastic; TrEMBL-Plants: tr|I3SMD8|I3SMD8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0387300 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04878 | CDD | 1 | 20.00 |