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IPR004881

Source: InterPro

Description

IPR004881 is a Ribosome biogenesis GTPase RsgA.

<p>This entry contains Escherichia coli (strain K12) RsgA, which plays a role in the late maturation steps of the functional core of the 30S ribosomal subunit. It removes RbfA from mature, but not immature, 30S ribosomes in a GTP-dependent manner [[cite:PUB00083883], [cite:PUB00083884]], and binds the 30S subunit making contact with the head, platform and rRNA helix 44 [[cite:PUB00076461], [cite:PUB00081044]]. RsgA (sometimes known as YjeQ or EngC) is an unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. It is dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in<i>k</i><sub>cat</sub>) or 70S (96 fold increase in<i>k</i><sub>cat</sub>) ribosomes [[cite:PUB00015323]]. The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin [[cite:PUB00017375]] streptomycin and spectinomycin [[cite:PUB00053979]]. This inhibition is not due to competition for binding sites on the 30S or 70S ribosome [[cite:PUB00053979]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003924
Molecular function GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Subterm of
GO:0005525
Molecular function GTP binding Interacting selectively and non-covalently with GTP, guanosine triphosphate.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v0950580.1
– Minichromosome maintenance family protein isoform 1 [Theobroma cacao] gi|508707992|gb|EOX99888.1|
Domains
18
LotjaGi3g1v0134500.1
– Small ribosomal subunit biogenesis GTPase RsgA; TAIR: AT1G67440.2 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|B0JW21|RSGA_MICAN Small ribosomal subunit biogenesis GTPase RsgA; TrEMBL-Plants: tr|A0A0L9T563|A0A0L9T563_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0134500
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00