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IPR004907 is a ATPase, V1 complex, subunit C.
<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra-and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release [[cite:PUB00020609]]. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [[cite:PUB00020608]].</p> <p>This entry represents the C subunit that is part of the V1 complex, and is localised to the interface between the V1 and V0 complexes [[cite:PUB00020629]]. This subunit does not show any homology with F-ATPase subunits. The C subunit plays an essential role in controlling the assembly of V-ATPase, acting as a flexible stator that holds together the catalytic (V1) and membrane (V0) sectors of the enzyme [[cite:PUB00020630]]. The release of subunit C from the ATPase complex results in the dissociation of the V1 and V0 subcomplexes, which is an important mechanism in controlling V-ATPase activity in cells.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Proton transmembrane transporter activity | Enables the transfer of a proton from one side of a membrane to the other. | ||
| Cellular component | Proton-transporting V-type ATPase, V1 domain | A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. | ||
| Biological process | Proton transmembrane transport | The directed movement of a proton across a membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: V-type proton ATPase subunit C-like [Glycine max] gi|356571620|ref|XP_003553974.1| | 7 | ||
| – | PREDICTED: V-type proton ATPase subunit C-like [Glycine max] gi|356561297|ref|XP_003548919.1| | 3 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|A0A1J7GSI6|A0A1J7GSI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0420700_LC | 7 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|I1N7Z4|I1N7Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0631600 | 10 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|A0A0B2R9D5|A0A0B2R9D5_GLYSO V-type proton ATPase subunit C; Found in the gene: LotjaGi1g1v0631600 | 10 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|A0A0B2R9D5|A0A0B2R9D5_GLYSO V-type proton ATPase subunit C; Found in the gene: LotjaGi1g1v0631600 | 10 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|A0A1J7GSI6|A0A1J7GSI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0468500_LC | 12 | ||
| – | V-type proton ATPase subunit C; TAIR: AT1G12840.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3); Swiss-Prot: sp|Q9SDS7|VATC_ARATH V-type proton ATPase subunit C; TrEMBL-Plants: tr|A0A1J7GSI6|A0A1J7GSI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0468500_LC | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 12.50 |