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IPR004953

Description

IPR004953 is a EB1, C-terminal.

<p>A group of microtubule-associated proteins called +TIPs (plus end tracking proteins), including EB1 (end-binding protein 1) family proteins, label growing microtubules ends specifically in diverse organisms and are implicated in spindle dynamics, chromosome segregation, and directing microtubules toward cortical sites. EB1 members have a bipartite composition: the N-terminal CH domain ([interpro:IPR001715]) mediates microtubule plus end localization and a C-terminal cargo binding domain (EB1-C) that captures cell polarity determinants. The EB1-C domain comprises a unique EB1-like sequence motif that acts as a binding site for other +TIP proteins. It interacts with the carboxy terminus of the adenomatous polyposis coli (APC) tumor suppressor, a well conserved +TIP phosphoprotein with a pivotal function in cell cycle regulation. Another binding partner of the EB1-C domain is the well conserved +TIP protein dynactin, a component of the large cytoplasmic dynein/dynactin complex [[cite:PUB00035338], [cite:PUB00032655], [cite:PUB00032323]].</p> <p>The ~80-residue EB1-C domain starts with a long smoothly curved helix (alpha1), which is followed by a hairpin connection leading to a short second helix (alpha2) running antiparallel to alpha1. The two parallel alpha1 helices of the EB1-C domain dimer wrap around each other in a slightly left-handed supercoil. The two alpha2 helices run antiparallel to helices alpha1 and form a similar fork in the opposite orientation and rotated by 90 degrees. As a result, two helical segments from each monomer form a four-helix bundle. The side chain forming the hydrophobic core of this bundle are highly conserved [[cite:PUB00032655], [cite:PUB00032323], [cite:PUB00035339]].</p> <p>Some protein known to contain an EB1-C domain are listed below:</p> <ul> <li>Yeast protein BIM1.</li> <li>Fission yeast microtubule integrity protein mal3.</li> <li>Vertebrate microtubule-associated protein RP/EB family member 1 (EB1).</li> <li>Vertebrate microtubule-associated protein RP/EB family member 2 (EB2 or RP1).</li> <li>Vertebrate microtubule-associated protein RP/EB family member 3 (EBF3).</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Microtubule binding Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
PREDICTED: microtubule-associated protein RP/EB family member 1B-like [Cicer arietinum] gi|502126762|ref|XP_004499427.1| 12
PREDICTED: microtubule-associated protein RP/EB family member 1-like [Glycine max] gi|356496933|ref|XP_003517319.1| 14
RP/EB family microtubule-associated protein; TAIR: AT5G62500.1 end binding protein 1B; Swiss-Prot: sp|Q9FJJ5|EB1B_ARATH Microtubule-associated protein RP/EB family member 1B; TrEMBL-Plants: tr|A0A072TJV8|A0A072TJV8_MEDTR RP/EB family microtubule-associated protein; Found in the gene: LotjaGi1g1v0218100 18
RP/EB family microtubule-associated protein; TAIR: AT5G67270.1 end binding protein 1C; Swiss-Prot: sp|Q9FGQ6|EB1C_ARATH Microtubule-associated protein RP/EB family member 1C; TrEMBL-Plants: tr|I3S6W4|I3S6W4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0405000 18
RP/EB family microtubule-associated protein; TAIR: AT3G47690.1 microtubule end binding protein EB1A; Swiss-Prot: sp|Q7XJ60|EB1A_ARATH Microtubule-associated protein RP/EB family member 1A; TrEMBL-Plants: tr|I1MTS4|I1MTS4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0249000 18
RP/EB family microtubule-associated protein; TAIR: AT5G62500.1 end binding protein 1B; Swiss-Prot: sp|Q9FJJ5|EB1B_ARATH Microtubule-associated protein RP/EB family member 1B; TrEMBL-Plants: tr|K7MKV8|K7MKV8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0249000 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67