Description

IPR004953 is a EB1, C-terminal.

<p>A group of microtubule-associated proteins called +TIPs (plus end tracking proteins), including EB1 (end-binding protein 1) family proteins, label growing microtubules ends specifically in diverse organisms and are implicated in spindle dynamics, chromosome segregation, and directing microtubules toward cortical sites. EB1 members have a bipartite composition: the N-terminal CH domain ([interpro:IPR001715]) mediates microtubule plus end localization and a C-terminal cargo binding domain (EB1-C) that captures cell polarity determinants. The EB1-C domain comprises a unique EB1-like sequence motif that acts as a binding site for other +TIP proteins. It interacts with the carboxy terminus of the adenomatous polyposis coli (APC) tumor suppressor, a well conserved +TIP phosphoprotein with a pivotal function in cell cycle regulation. Another binding partner of the EB1-C domain is the well conserved +TIP protein dynactin, a component of the large cytoplasmic dynein/dynactin complex [[cite:PUB00035338], [cite:PUB00032655], [cite:PUB00032323]].</p> <p>The ~80-residue EB1-C domain starts with a long smoothly curved helix (alpha1), which is followed by a hairpin connection leading to a short second helix (alpha2) running antiparallel to alpha1. The two parallel alpha1 helices of the EB1-C domain dimer wrap around each other in a slightly left-handed supercoil. The two alpha2 helices run antiparallel to helices alpha1 and form a similar fork in the opposite orientation and rotated by 90 degrees. As a result, two helical segments from each monomer form a four-helix bundle. The side chain forming the hydrophobic core of this bundle are highly conserved [[cite:PUB00032655], [cite:PUB00032323], [cite:PUB00035339]].</p> <p>Some protein known to contain an EB1-C domain are listed below:</p> <ul> <li>Yeast protein BIM1.</li> <li>Fission yeast microtubule integrity protein mal3.</li> <li>Vertebrate microtubule-associated protein RP/EB family member 1 (EB1).</li> <li>Vertebrate microtubule-associated protein RP/EB family member 2 (EB2 or RP1).</li> <li>Vertebrate microtubule-associated protein RP/EB family member 3 (EBF3).</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: