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IPR027328 is a Microtubule-associated protein RP/EB.
<p>This entry represents the microtubule-associated protein RP/EB (MAPRE) family, including MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2), MAPRE3 (EBF3, also known as EB3) and their homologues from eukaryotes. Despite their high protein sequence conservation, the individual EBs exhibit different regulatory and functional properties [[cite:PUB00066544]]. For instance, EB1 and EB3, but not EB2, promote persistent microtubule growth by suppressing catastrophes [[cite:PUB00051069]].</p> <p>EB1 contains an N-terminal calponin homology (CH) domain that is responsible for the interaction with microtubules (MTs), and a C-terminal coiled coil domain that extends into a four-helix bundle, required for dimer formation [[cite:PUB00063866]]. Through their C-terminal sequences, EBs interact with most other known +TIPs (plus end tracking proteins) and recruit many of them to the growing MT ends [[cite:PUB00063861], [cite:PUB00063866]]. EB1 is involved in MT anchoring at the centrosome and cell migration [[cite:PUB00063867]].</p> <p>EB2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion [[cite:PUB00063864]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Microtubule end binding protein EB1A [Theobroma cacao] gi|508774541|gb|EOY21797.1| | 7 | ||
| – | PREDICTED: microtubule-associated protein RP/EB family member 1B-like [Cicer arietinum] gi|502126762|ref|XP_004499427.1| | 12 | ||
| – | PREDICTED: microtubule-associated protein RP/EB family member 1-like [Glycine max] gi|356496933|ref|XP_003517319.1| | 14 | ||
| – | Microtubule end binding protein EB1A [Theobroma cacao] gi|508774541|gb|EOY21797.1| | 12 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT3G47690.1 microtubule end binding protein EB1A; Swiss-Prot: sp|Q7XJ60|EB1A_ARATH Microtubule-associated protein RP/EB family member 1A; TrEMBL-Plants: tr|B9R983|B9R983_RICCO Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0141300_LC | 12 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT5G62500.1 end binding protein 1B; Swiss-Prot: sp|Q9FJJ5|EB1B_ARATH Microtubule-associated protein RP/EB family member 1B; TrEMBL-Plants: tr|A0A072TJV8|A0A072TJV8_MEDTR RP/EB family microtubule-associated protein; Found in the gene: LotjaGi1g1v0218100 | 18 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT5G67270.1 end binding protein 1C; Swiss-Prot: sp|Q9FGQ6|EB1C_ARATH Microtubule-associated protein RP/EB family member 1C; TrEMBL-Plants: tr|I3S6W4|I3S6W4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0405000 | 18 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT5G67270.1 end binding protein 1C; Swiss-Prot: sp|Q9FGQ6|EB1C_ARATH Microtubule-associated protein RP/EB family member 1C; TrEMBL-Plants: tr|I3S6W4|I3S6W4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0405000 | 10 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT3G47690.1 microtubule end binding protein EB1A; Swiss-Prot: sp|Q7XJ60|EB1A_ARATH Microtubule-associated protein RP/EB family member 1A; TrEMBL-Plants: tr|I1MTS4|I1MTS4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0249000 | 18 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT5G62500.1 end binding protein 1B; Swiss-Prot: sp|Q9FJJ5|EB1B_ARATH Microtubule-associated protein RP/EB family member 1B; TrEMBL-Plants: tr|K7MKV8|K7MKV8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0249000 | 15 | ||
| – | RP/EB family microtubule-associated protein; TAIR: AT3G47690.1 microtubule end binding protein EB1A; Swiss-Prot: sp|Q7XJ60|EB1A_ARATH Microtubule-associated protein RP/EB family member 1A; TrEMBL-Plants: tr|I1MTS5|I1MTS5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0249000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |