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IPR005144

Source: InterPro

Description

IPR005144 is a ATP-cone domain.

<p>The ATP-cone is an evolutionarily mobile, ATP-binding regulatory domain which is found in a variety of proteins including ribonucleotide reductases, phosphoglycerate kinases and transcriptional regulators [[cite:PUB00007748]].</p> <p>In ribonucleotide reductase protein R1 ([swissprot:P28903]) from Escherichia coli this domain is located at the N terminus, and is composed mostly of helices [[cite:PUB00005954]]. It forms part of the allosteric effector region and contains the general allosteric activity site in a cleft located at the tip of the N-terminal region [[cite:PUB00005953]]. This site binds either ATP (activating) or dATP (inhibitory), with the base bound in a hydrophobic pocket and the phosphates bound to basic residues. Substrate binding to this site is thought to affect enzyme activity by altering the relative positions of the two subunits of ribonucleotide reductase.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj1g3v1222710.1
– PREDICTED: ribonucleoside-diphosphate reductase large subunit-like [Glycine max] gi|356509012|ref|XP_003523246.1|
Domains
18
LotjaGi1g1v0314100.1
– Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|I1JY66|I1JY66_SOYBN Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi1g1v0314100
Domains
19
LotjaGi4g1v0406000.1
– Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000
Domains
19
LotjaGi4g1v0406000.2
– Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000
Domains
19
LotjaGi4g1v0406000.3
– Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000
Domains
19
LotjaGi4g1v0406000.4
– Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01679 CDD 1 16.67