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IPR013346 is a Ribonucleotide reductase, class I, alpha subunit, C-terminal.
<p>This entry represents the C-terminal region of the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen [[cite:PUB00020744]]. Escherichia coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains [[cite:PUB00005954], [cite:PUB00020990]]). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. Members of this group are found in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribonucleoside-diphosphate reductase large subunit-like [Glycine max] gi|356509012|ref|XP_003523246.1| | 18 | ||
| – | PREDICTED: ribonucleoside-diphosphate reductase large subunit [Glycine max] gi|356512785|ref|XP_003525096.1| | 16 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|I1JY66|I1JY66_SOYBN Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi1g1v0314100 | 19 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|I1JY66|I1JY66_SOYBN Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi1g1v0314100 | 16 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000 | 19 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000 | 19 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000 | 19 | ||
| – | Ribonucleoside-diphosphate reductase; TAIR: AT2G21790.1 ribonucleotide reductase 1; Swiss-Prot: sp|Q9SJ20|RIR1_ARATH Ribonucleoside-diphosphate reductase large subunit; TrEMBL-Plants: tr|A0A0B2RLF4|A0A0B2RLF4_GLYSO Ribonucleoside-diphosphate reductase; Found in the gene: LotjaGi4g1v0406000 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01679 | CDD | 1 | 12.50 |