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IPR005375

Source: InterPro

Description

IPR005375 is a Ubiquitin-fold modifier 1.

<p>This entry represents Ufm1 (ubiquitin-fold modifier), which is a ubiquitin-like protein with structural similarities to ubiquitin [[cite:PUB00034737], [cite:PUB00034740]]. Ufm1 is one of a number of ubiquitin-like modifiers that conjugate to target proteins in cells through Uba5 (E1) and Ufc1 (E2). The Ufm1-system is conserved in metazoa and plants, suggesting it has a potential role in multicellular organisms [[cite:PUB00034738]]. Human Ufm1 is synthesized as a precursor consisting of 85 amino-acid residues. Prior to activation by Uba5, the extra amino acids at the C-terminal region of Ufm1 are removed to expose Gly, which is necessary for conjugation to target molecule(s). C-terminal processing of Ufm1 requires two specific cysteine peptidases ([interpro:IPR012462]): UfSP1 and UfSP2; both peptidases are also able to release Ufm1 from Ufm1-conjugated cellular proteins. UfSP2 is present in most, if not all, of multi-cellular organisms including plant, nematode, fly, and mammal, whereas UfSP1 is not present in plants and nematodes [[cite:PUB00034739]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0071569
Biological process Protein ufmylation Covalent attachment of the ubiquitin-like protein UFM1 to another protein.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0318879.1
– PREDICTED: ubiquitin-fold modifier 1-like [Glycine max] gi|356552829|ref|XP_003544765.1|
Domains
8
LotjaGi1g1v0153500.1
– Ubiquitin-fold modifier 1; TAIR: AT1G77710.1 ubiquitin-fold modifier; Swiss-Prot: sp|Q9CA23|UFM1_ARATH Ubiquitin-fold modifier 1; TrEMBL-Plants: tr|I1MAL3|I1MAL3_SOYBN Ubiquitin-fold modifier 1; Found in the gene: LotjaGi1g1v0153500
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01766 CDD 1 50.00