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IPR005708

Source: InterPro

Description

IPR005708 is a Homogentisate 1,2-dioxygenase.

<p>Alkaptonuria (AKU), a rare hereditary disorder, was the first disease to be interpreted as an inborn error of metabolism. The deficiency causes homogentisic aciduria, ochronosis, and arthritis. AKU patients are deficient for homogentisate 1,2 dioxygenase (HGD) ([ec:1.13.11.5]), the enzyme that mediates the conversion of homogentisate to maleylacetoacetate, a step in the catabolism of both tyrosine and phenylalanine. The structure of this protein shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is coordinated near the interface between the trimers [[cite:PUB00101169], [cite:PUB00009903]].</p> <p>This group of proteins includes human HDG and homologues from eukaryotes, bacteria and some archaeal species.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004411
Molecular function Homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
Subterm of
GO:0006559
Biological process L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
Subterm of
GO:0006570
Biological process Tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj3g3v0428820.1
– PREDICTED: homogentisate 1,2-dioxygenase-like [Glycine max] gi|356543235|ref|XP_003540068.1|
Domains
7
Lj3g3v0428820.2
– PREDICTED: homogentisate 1,2-dioxygenase-like [Glycine max] gi|356543235|ref|XP_003540068.1|
Domains
8
LotjaGi3g1v0044000.1
– Homogentisate 1,2-dioxygenase; TAIR: AT5G54080.1 homogentisate 1,2-dioxygenase; Swiss-Prot: sp|Q9ZRA2|HGD_ARATH Homogentisate 1,2-dioxygenase; TrEMBL-Plants: tr|I1LSW3|I1LSW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0044000
Domains
9
LotjaGi3g1v0044000.2
– Homogentisate 1,2-dioxygenase; TAIR: AT5G54080.1 homogentisate 1,2-dioxygenase; Swiss-Prot: sp|Q9ZRA2|HGD_ARATH Homogentisate 1,2-dioxygenase; TrEMBL-Plants: tr|I1LSW3|I1LSW3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0044000
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01015 TIGRFAM 1 25.00