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IPR005849

Source: InterPro

Description

IPR005849 is a Galactose-1-phosphate uridyl transferase, N-terminal.

<p>Galactose-1-phosphate uridyl transferase catalyses the conversion of UDP-glucose and alpha-D-galactose 1-phosphate to alpha-D-glucose 1-phosphate and UDP-galactose during galactose metabolism. The enzyme is present in prokaryotes and eukaryotes. Defects in GalT in humans is the cause of galactosemia, an inherited disorder of galactose metabolism that leads to jaundice, cataracts and mental retardation.</p> <p>This domain describes the C-terminal of Galactose-1-phosphate uridyl transferase. SCOP reports fold duplication of the C-terminal with the N-terminal domain. Both are involved in Zn and Fe binding.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006012
Biological process Galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
Subterm of
GO:0008108
Molecular function UDP-glucose:hexose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v0227390.1
– PREDICTED: probable galactose-1-phosphate uridyl transferase-like [Glycine max] gi|356559549|ref|XP_003548061.1|
Domains
10
LotjaGi6g1v0032000.1
– Galactose-1-phosphate uridylyltransferase; TAIR: AT5G18200.1 putative galactose-1-phosphate uridyltransferase; Swiss-Prot: sp|Q9FK51|AGLUP_ARATH ADP-glucose phosphorylase; TrEMBL-Plants: tr|I1MNU2|I1MNU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032000
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00209 TIGRFAM 1 50.00