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IPR005995

Source: InterPro

Description

IPR005995 is a Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent.

<p>This 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM) is a metalloenzyme found particularly in eubacteria and higher plants. It is distantly related to archaeal iPGAM ([interpro:IPR004456]) and distinct from the unrelated cofactor-dependent PGAM. Activity has been demonstrated for proteins from a variety of organisms, including Pseudomonas syringae pv. tomato [[cite:PUB00014416]], Bacillus subtilis [[cite:PUB00014367]], Bacillus stearothermophilus [[cite:PUB00014404]], maize [[cite:PUB00002717]], castor bean [[cite:PUB00014371]], and Trypanosoma brucei [[cite:PUB00014401]]. The structure of the B. stearothermophilus enzyme has two domains [[cite:PUB00014365]]. Residues 1-76 and 311-511 form the phosphatase domain, containing the active site residue and two metal-binding sites. This domain is similar to alkaline phosphatase and arylsulphatase, which are members of the SCOP alkaline phosphatase-like superfamily, but there is meagre sequence similarity outside of the metal-binding segments. Residues 77-310 form the phosphotransferase domain, which is poorly conserved (or perhaps unrelated) in the archaeal enzymes.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004619
Molecular function Phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
Subterm of
GO:0006007
Biological process Glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj1g3v2570560.1
– PREDICTED: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [Glycine max] gi|356568270|ref|XP_003552336.1|
Domains
15
Lj3g3v0461640.1
– PREDICTED: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [Glycine max] gi|356568270|ref|XP_003552336.1|
Domains
15
LotjaGi1g1v0461200.1
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT1G09780.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|P35493|PMGI_RICCO 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A0R0F2Z4|A0A0R0F2Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0461200
Domains
16
LotjaGi1g1v0461200.2
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT1G09780.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|P35493|PMGI_RICCO 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A0R0F2Z4|A0A0R0F2Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0461200
Domains
16
LotjaGi1g1v0461200.3
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT1G09780.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|P35493|PMGI_RICCO 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A0R0F2Z4|A0A0R0F2Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0461200
Domains
15
LotjaGi1g1v0461200.4
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT1G09780.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|P35493|PMGI_RICCO 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A0R0F2Z4|A0A0R0F2Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0461200
Domains
16
LotjaGi3g1v0053400.1
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT3G08590.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|Q42908|PMGI_MESCR 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A1J7H4F6|A0A1J7H4F6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0053400
Domains
16
LotjaGi3g1v0053400.2
– 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TAIR: AT3G08590.1 Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Swiss-Prot: sp|Q42908|PMGI_MESCR 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TrEMBL-Plants: tr|A0A1J7H4F6|A0A1J7H4F6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0053400
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd16010 CDD 1 12.50