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IPR006113 is a 6-phosphogluconate dehydrogenase, decarboxylating.
<p>6-Phosphogluconate dehydrogenase ([ec:1.1.1.44]) (6PGD) is a key enzyme that produces NADPH by converting 6-phospho D-gluconolactone to D-ribulose 5-phosphate in the pentose phosphate pathways (PPP) [[cite:PUB00002112], [cite:PUB00001132]]. NADPH provides the major reducing power required for lipid production and protecting the cell against oxidative stress. 6PGD has been extensively studied with respect to kinetics, regulation, role in pentose-shunt production of NADPH and lipogenesis, and population genetics [[cite:PUB00073768]]. 6PGD is associated with several human disorders including cancer and Alzheimer's disease. The structure of budding yeast 6PGD (also known as Gnd1) has been revealed [[cite:PUB00043231]].</p> <p>Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [[cite:PUB00003806]]. The protein is a homodimer in which the monomers act independently [[cite:PUB00001132]]: each contains a large, mainly α-helical domain and a smaller β-α-β domain, containing a mixed parallel and anti-parallel 6-stranded β sheet [[cite:PUB00043231], [cite:PUB00001132]]. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket [[cite:PUB00001132]].</p> <p>Bacillus subtilis contains three classes of 6-phosphogluconate dehydrogenases (6PGD), including Gnd (YqjI), GntZ and YqeC (truncated 6PGD). Gnd (YqjI) and GntZ are included in this entry. YgjiI is NADP+ dependent, while GntZ and YqeC are NAD+-dependent [[cite:PUB00073769]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphogluconate dehydrogenase (decarboxylating) activity | Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. | ||
| Biological process | Pentose-phosphate shunt | The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356573793|ref|XP_003555040.1| | 19 | ||
| – | PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356526585|ref|XP_003531897.1| | 20 | ||
| – | PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356526585|ref|XP_003531897.1| | 21 | ||
| – | PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic-like [Cicer arietinum] gi|502139109|ref|XP_004503648.1| | 24 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900 | 20 | ||
| – | 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT5G41670.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FFR3|6PGD2_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic; TrEMBL-Plants: tr|A0A072TUR1|A0A072TUR1_MEDTR 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi4g1v0432400 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 9.09 |