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IPR006115

Source: InterPro

Description

IPR006115 is a 6-phosphogluconate dehydrogenase, NADP-binding.

<p>6-Phosphogluconate dehydrogenase ([ec:1.1.1.44]) (6PGD) is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP) [[cite:PUB00002112], [cite:PUB00001132]]. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [[cite:PUB00003806]]. The protein is a homodimer in which the monomers act independently [[cite:PUB00001132]]: each contains a large, mainly α-helical domain and a smaller β-α-β domain, containing a mixed parallel and anti-parallel six-stranded β-sheet [[cite:PUB00001132]]. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket [[cite:PUB00001132]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0050661
Molecular function NADP binding Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
Subterm of

Associated Lotus transcripts 38

Transcript Name Description Predicted domains Domain count
Lj0g3v0078409.1
– PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470127985|ref|XP_004299936.1|
Domains
15
Lj0g3v0172259.1
– PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356573793|ref|XP_003555040.1|
Domains
19
Lj0g3v0201049.1
– Ketose-bisphosphate aldolase class-II family protein isoform 3 [Theobroma cacao] gi|508774098|gb|EOY21354.1|
Domains
11
Lj0g3v0336589.1
– Ketose-bisphosphate aldolase class-II family protein isoform 1 [Theobroma cacao] gi|508774096|gb|EOY21352.1|
Domains
32
Lj0g3v0336589.3
– Ketose-bisphosphate aldolase class-II family protein isoform 2 [Theobroma cacao] gi|508774097|gb|EOY21353.1|
Domains
23
Lj1g3v3101570.1
– PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356526585|ref|XP_003531897.1|
Domains
20
Lj1g3v3101570.2
– PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating-like isoform 3 [Glycine max] gi|356526585|ref|XP_003531897.1|
Domains
21
Lj3g3v0323280.1
– Hydroxyacid dehydrogenase/reductase; 6-phosphogluconate dehydrogenase, C-terminal-like [Medicago truncatula] gi|124359345|gb|ABD28508.2|
Domains
15
Lj3g3v2387600.1
– PREDICTED: glyoxylate/succinic semialdehyde reductase 1-like [Cicer arietinum] gi|502157000|ref|XP_004510724.1|
Domains
13
Lj4g3v3002490.1
– PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic-like [Cicer arietinum] gi|502139109|ref|XP_004503648.1|
Domains
24
Lj4g3v3043930.1
– PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial-like [Cicer arietinum] gi|502138668|ref|XP_004503489.1|
Domains
15
Lj5g3v1999260.1
– PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470127985|ref|XP_004299936.1|
Domains
11
Lj6g3v1629990.1
– PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial-like isoform X1 [Cicer arietinum] gi|502080130|ref|XP_004486468.1|
Domains
19
LotjaGi1g1v0522700.1
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700
Domains
20
LotjaGi1g1v0522700.2
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700
Domains
20
LotjaGi1g1v0522700.3
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1KWM7|I1KWM7_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi1g1v0522700
Domains
20
LotjaGi2g1v0196100.1
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.2
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.3
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.4
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.5
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.6
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.7
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0196100.8
– Fructose-bisphosphate aldolase; TAIR: AT1G18270.1 ketose-bisphosphate aldolase class-II family protein; Swiss-Prot: sp|Q46888|YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ; TrEMBL-Plants: tr|K7L0V1|K7L0V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196100
Domains
31
LotjaGi2g1v0272900.1
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900
Domains
20
LotjaGi2g1v0272900.2
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900
Domains
20
LotjaGi2g1v0272900.3
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT3G02360.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FWA3|6GPD3_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 3; TrEMBL-Plants: tr|I1N6I4|I1N6I4_SOYBN 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi2g1v0272900
Domains
20
LotjaGi3g1v0026900.1
– 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900
Domains
15
LotjaGi3g1v0026900.2
– 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT1G17650.1 glyoxylate reductase 2; Swiss-Prot: sp|F4I907|GLYR2_ARATH Glyoxylate/succinic semialdehyde reductase 2, chloroplastic; TrEMBL-Plants: tr|G7IUG9|G7IUG9_MEDTR Glyoxylate/succinic semialdehyde reductase; Found in the gene: LotjaGi3g1v0026900
Domains
15
LotjaGi3g1v0391100.1
– 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT3G25530.1 glyoxylate reductase 1; Swiss-Prot: sp|Q9LSV0|GLYR1_ARATH Glyoxylate/succinic semialdehyde reductase 1; TrEMBL-Plants: tr|A0A1J7GPF6|A0A1J7GPF6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391100
Domains
17
LotjaGi4g1v0432400.1
– 6-phosphogluconate dehydrogenase, decarboxylating; TAIR: AT5G41670.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9FFR3|6PGD2_ARATH 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic; TrEMBL-Plants: tr|A0A072TUR1|A0A072TUR1_MEDTR 6-phosphogluconate dehydrogenase, decarboxylating; Found in the gene: LotjaGi4g1v0432400
Domains
23
LotjaGi4g1v0445200.1
– 6-phosphogluconate dehydrogenase family protein; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|A0A072TUY6|A0A072TUY6_MEDTR 6-phosphogluconate dehydrogenase NAD-binding domain protein; Found in the gene: LotjaGi4g1v0445200
Domains
13
LotjaGi4g1v0445200.2
– 6-phosphogluconate dehydrogenase family protein; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|I1K5Z3|I1K5Z3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0445200
Domains
15
LotjaGi5g1v0299400_LC.1
– 3-hydroxyisobutyrate dehydrogenase, putative; TAIR: AT4G29120.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SZE1|3HID1_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 1, mitochondrial; TrEMBL-Plants: tr|B9GEW0|B9GEW0_POPTR 6-phosphogluconate dehydrogenase NAD-binding domain-containing family protein; Found in the gene: LotjaGi5g1v0299400_LC
Domains
11
LotjaGi6g1v0270100.1
– 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100
Domains
18
LotjaGi6g1v0270100.2
– 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100
Domains
17
LotjaGi6g1v0270100.3
– 3-hydroxyisobutyrate dehydrogenase; TAIR: AT4G20930.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q9SUC0|3HIDH_ARATH Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A151T609|A0A151T609_CAJCA 3-hydroxyisobutyrate dehydrogenase; Found in the gene: LotjaGi6g1v0270100
Domains
17
LotjaGi6g1v0360300.1
– 6-phosphogluconate dehydrogenase-like protein; TAIR: AT1G71180.1 6-phosphogluconate dehydrogenase family protein; Swiss-Prot: sp|Q949M8|3HID3_ARATH Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial; TrEMBL-Plants: tr|W9QFQ0|W9QFQ0_9ROSA Putative oxidoreductase ykwC; Found in the gene: LotjaGi6g1v0360300
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51735 SUPERFAMILY 1 2.63