Description

IPR006175 is a YjgF/YER057c/UK114 family.

<p>The YjgF/YER057c/UK114 family (also known as the Rid family) of proteins is conserved in all domains of life [[cite:PUB00064878]]. A phylogenetic analysis applied by Lambrecht <i>et al.</i> has divided the Rid family into a widely distributed archetypal RidA (YjgF) subfamily and seven other subfamilies (Rid1 to Rid7) that are largely confined to bacteria and often co-occur in the same organism with RidA and each other [[cite:PUB00076979]]. Although the family members share high levels of protein sequence and structure similarity, their functions vary widely across different species [[cite:PUB00076980]].</p> <p>Structurally, these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [[cite:PUB00054810], [cite:PUB00028737], [cite:PUB00028112]].</p> <p>This family includes:</p> <ul> <li>YjgF (also known as RidA or 2-iminobutanoate/2-iminopropanoate deaminase), which displays enamine/imine deaminase activity and can accelerate the release of ammonia from reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA) [[cite:PUB00064878], [cite:PUB00074576]]</li> <li>the yeast growth inhibitor YER057c (protein HMF1) that appears to play a role in the regulation of metabolic pathways and cell differentiation [[cite:PUB00028113]]</li> <li>the mammalian 14.5kDa translational inhibitor protein UK114, also known as L-PSP (liver perchloric acid-soluble protein), with endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes [[cite:PUB00007949]]</li> <li>RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate [[cite:PUB00056792]] </li> <li>YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes [[cite:PUB00006517]]</li> </ul> <p>Structurally, these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [[cite:PUB00054810], [cite:PUB00028737], [cite:PUB00028112]].</p> <p>This family includes:</p> <ul> <li>Bacterial YjgF (also known as RidA or 2-iminobutanoate/2-iminopropanoate deaminase), which displays enamine/imine deaminase activity and can accelerate the release of ammonia from reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA) [[cite:PUB00064878], [cite:PUB00074576]]</li> <li>The yeast growth inhibitor YER057c (protein HMF1) that appears to play a role in the regulation of metabolic pathways and cell differentiation [[cite:PUB00028113]]</li> <li>The mammalian 14.5kDa translational inhibitor protein or UK114 antigen homologue, also known as L-PSP (liver perchloric acid-soluble protein), which has been reported to show endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes [[cite:PUB00007949]] and be responsible for the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism [[cite:PUB00064878], [cite:PUB00103945]]</li> <li>RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate [[cite:PUB00056792]]</li> <li>YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes [[cite:PUB00006517]]</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: