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IPR006223 is a Glycine cleavage system T protein.
<p>The glycine cleavage system (GCS) is a multienzyme system composed of proteins P, H, T, and L, that catalyses the reversible oxidation of glycine. The T protein is an aminomethyl transferase [ec:2.1.2.10] that catalyses the following reaction:</p> <p> <reaction> (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH<sub>3</sub> + dihydrolipoylprotein </reaction> </p> <p>The glycine cleavage system is found in bacteria and the mitochondria of eukaryotes. Mutations in the human T-protein gene are known to cause nonketotic hyperglycinemia [[cite:PUB00069711]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminomethyltransferase activity | Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. | ||
| Biological process | Glycine catabolic process | The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [Glycine max] gi|356531975|ref|XP_003534551.1| | 17 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00528 | TIGRFAM | 1 | 25.00 |