Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR006223 is a Glycine cleavage system T protein.
<p>This entry represents aminomethyltransferases GcvT, part of the glycine cleavage multienzyme complex (GCV).</p> <p>The glycine cleavage multienzyme complex (GCV) catalyses the catabolism of glycine in eukaryotes. GcvT (aminomethyltransferase, [ec:2.1.2.10]) is a folate-dependent enzyme that catalyses the release of ammonia and the transfer of the methylene carbon unit (C1 unit) to tetrahydrofolate (H4folate) from the aminomethyl intermediate attached to the lipoate cofactor of H-protein [[cite:PUB00001870], [cite:PUB00038140]]. GCV is found in bacteria and the mitochondria of eukaryotes. Mutations in the human GcvT gene are known to cause nonketotic hyperglycinemia [[cite:PUB00069711]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminomethyltransferase activity | Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. | ||
| Biological process | Glycine catabolic process | The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [Glycine max] gi|356531975|ref|XP_003534551.1| | 17 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00528 | TIGRFAM | 1 | 25.00 |