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IPR006222 is a Aminomethyltransferase, folate-binding domain.
<p>This entry represents the N-terminal in glycine cleavage T-proteins, which are part of the glycine cleavage multienzyme complex (GcvT) found in bacteria and the mitochondria of eukaryotes. This domain is also found in YgfZ proteins. This domain represents a possible folate-binding domain. Trimethylamine-oxide aldolase is also represented by this entry; it catalyses the conversion of trimethylamine N-oxide (TMAO) to dimethylamine (DMA) and formaldehyde [[cite:PUB00093079]].</p> <p>The glycine cleavage multienzyme complex (GCV) catalyses the catabolism of glycine in eukaryotes. GcvT (aminomethyltransferase, [ec:2.1.2.10]) is a folate-dependent enzyme that catalyses the release of ammonia and the transfer of the methylene carbon unit (C1 unit) to tetrahydrofolate (H4folate) from the aminomethyl intermediate attached to the lipoate cofactor of H-protein [[cite:PUB00001870], [cite:PUB00038140]]. GCV is found in bacteria and the mitochondria of eukaryotes. Mutations in the human GcvT gene are known to cause nonketotic hyperglycinemia [[cite:PUB00069711]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aminomethyltransferase-like [Glycine max] gi|356512604|ref|XP_003525008.1| | 16 | ||
| – | 8 | |||
| – | PREDICTED: LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [Glycine max] gi|356531975|ref|XP_003534551.1| | 17 | ||
| – | Aminomethyltransferase; TAIR: AT1G60990.1 Glycine cleavage T-protein family; Swiss-Prot: sp|Q681Y3|Y1099_ARATH Putative transferase At1g60990, chloroplastic; TrEMBL-Plants: tr|A0A151UBV7|A0A151UBV7_CAJCA Aminomethyltransferase; Found in the gene: LotjaGi4g1v0388400 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G60990.1 Glycine cleavage T-protein family; Swiss-Prot: sp|Q681Y3|Y1099_ARATH Putative transferase At1g60990, chloroplastic; TrEMBL-Plants: tr|A0A151UBV7|A0A151UBV7_CAJCA Aminomethyltransferase; Found in the gene: LotjaGi4g1v0388400 | 14 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00528 | TIGRFAM | 1 | 12.50 |