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IPR006222 is a Aminomethyltransferase, folate-binding domain.
<p>This domain is found at the N terminus of glycine cleavage T-proteins, which are part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein (aminomethyltransferase, [ec:2.1.2.10]) is a folate-dependent enzyme that catalyses the release of ammonia and the transfer of the methylene carbon unit (C1 unit) to tetrahydrofolate (H4folate) from the aminomethyl intermediate attached to the lipoate cofactor of H-protein [[cite:PUB00001870], [cite:PUB00038140]].</p> <p>This domain is also found in YgfZ proteins. YgfZ in E.coli is a folate binding protein involved in RNA modification and regulation of chromosomal replication initiation [[cite:PUB00043084]]. YgfZ is not an aminomethyltransferase but is likely a folate-dependent regulatory protein [[cite:PUB00022265]]. This domain could represent a folate-binding domain.</p> <p>Trimethylamine-oxide aldolase is another member of this domain family. This enzyme calalyses the conversion of trimethylamine N-oxide (TMAO) to dimethylamine (DMA) and formaldehyde [[cite:PUB00093079]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aminomethyltransferase-like [Glycine max] gi|356512604|ref|XP_003525008.1| | 16 | ||
| – | 8 | |||
| – | PREDICTED: LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [Glycine max] gi|356531975|ref|XP_003534551.1| | 17 | ||
| – | Aminomethyltransferase; TAIR: AT1G60990.1 Glycine cleavage T-protein family; Swiss-Prot: sp|Q681Y3|Y1099_ARATH Putative transferase At1g60990, chloroplastic; TrEMBL-Plants: tr|A0A151UBV7|A0A151UBV7_CAJCA Aminomethyltransferase; Found in the gene: LotjaGi4g1v0388400 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G60990.1 Glycine cleavage T-protein family; Swiss-Prot: sp|Q681Y3|Y1099_ARATH Putative transferase At1g60990, chloroplastic; TrEMBL-Plants: tr|A0A151UBV7|A0A151UBV7_CAJCA Aminomethyltransferase; Found in the gene: LotjaGi4g1v0388400 | 14 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 | ||
| – | Aminomethyltransferase; TAIR: AT1G11860.1 Glycine cleavage T-protein family; Swiss-Prot: sp|P49364|GCST_PEA Aminomethyltransferase, mitochondrial; TrEMBL-Plants: tr|I3SSE7|I3SSE7_LOTJA Aminomethyltransferase; Found in the gene: LotjaGi6g1v0293200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00528 | TIGRFAM | 1 | 12.50 |