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IPR006254 is a Isocitrate lyase.
<p>Isocitrate lyase ([ec:4.1.3.1]) [[cite:PUB00005064], [cite:PUB00002339]] is an enzyme that catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle (also known as the TCA cycle) in bacteria, fungi and plants. A cysteine, a histidine and a glutamate or aspartate have been found to be important for the enzyme's catalytic activity. Only one cysteine residue is conserved between the sequences of the fungal, plant and bacterial enzymes; it is located in the middle of a conserved hexapeptide.</p> <p>Mitochondrial 2-methylisocitrate lyase ICL2 from the yeast Saccharomyces cerevisiae does not act on isocitrate but on 2-methylisocitrate. It catalyses the formation of pyruvate and succinate during the metabolism of endogenous propionyl-CoA [[cite:PUB00100290]]. Methylisocitrate lyase, mitochondrial from the filamentous fungus Aspergillus nidulans is responsible for the same reaction [[cite:PUB00100291]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Isocitrate lyase activity | Catalysis of the reaction: isocitrate = glyoxylate + succinate. | ||
| Biological process | Carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: isocitrate lyase 2-like [Glycine max] gi|356542840|ref|XP_003539873.1| | 11 | ||
| – | Isocitrate lyase; TAIR: AT3G21720.1 isocitrate lyase; Swiss-Prot: sp|P45457|ACEA2_SOYBN Isocitrate lyase 2; TrEMBL-Plants: tr|I1LRR9|I1LRR9_SOYBN Isocitrate lyase; Found in the gene: LotjaGi3g1v0464400 | 14 | ||
| – | Isocitrate lyase; TAIR: AT3G21720.1 isocitrate lyase; Swiss-Prot: sp|P45457|ACEA2_SOYBN Isocitrate lyase 2; TrEMBL-Plants: tr|I1LRR9|I1LRR9_SOYBN Isocitrate lyase; Found in the gene: LotjaGi3g1v0464400 | 14 | ||
| – | Isocitrate lyase; TAIR: AT3G21720.1 isocitrate lyase; Swiss-Prot: sp|P45457|ACEA2_SOYBN Isocitrate lyase 2; TrEMBL-Plants: tr|I1LRR9|I1LRR9_SOYBN Isocitrate lyase; Found in the gene: LotjaGi3g1v0464400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00377 | CDD | 1 | 25.00 |