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IPR006258 is a Dihydrolipoamide dehydrogenase.
<p>These sequences represent dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N terminus contains a redox-active disulphide.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Dihydrolipoyl dehydrogenase activity | Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydrolipoyl dehydrogenase, mitochondrial-like [Cicer arietinum] gi|502150750|ref|XP_004508105.1| | 18 | ||
| – | Dihydrolipoyl dehydrogenase [Medicago truncatula] gi|357478937|ref|XP_003609754.1| | 25 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT1G48030.1 mitochondrial lipoamide dehydrogenase 1; Swiss-Prot: sp|P31023|DLDH_PEA Dihydrolipoyl dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A1J7G486|A0A1J7G486_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0334700 | 20 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.1 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.2 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |