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IPR001100 is a Pyridine nucleotide-disulphide oxidoreductase, class I.
<p>The pyridine nucleotide-disulphide reductases (PNDR) use the isoalloxazine ring of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step, the reduced disulphide reduces the substrate. On the basis of sequence and structural similarities [[cite:PUB00004100]], PNDR can be categorised into 2 groups.</p> <p>Class I includes glutathione reductase, trypanothione reductase, lipoamide dehydrogenase and mercuric reductase. They cover a wide range of catalytic functions: glutathione reductase ensures that the cell has enough reduced glutathione to maintain protein thiol groups in the reduced state [[cite:PUB00000154]]; trypanothione reductase carries out the analogous reaction in trypanosomal cells (trypanothione is an analogue of glutathione) [[cite:PUB00000284]]; lipoamide dehydrogenase, the E3 component of alpha-ketoacid dehydrogenase multienzyme complex, oxidises the dihydrolypoyl groups of lipoate acyltransferase, and so couples glycolysis to the tricarboxylic acid cycle [[cite:PUB00000149]]; and mercuric reductase enables bacteria to detoxify the mercuric ion by reducing it to elemental mercury, which evaporates from the cell [[cite:PUB00004586]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|A0A151S7T2|A0A151S7T2_CAJCA Glutathione reductase, cytosolic; Found in the gene: LotjaGi2g1v0119800 | 21 | ||
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|A0A151S7T2|A0A151S7T2_CAJCA Glutathione reductase, cytosolic; Found in the gene: LotjaGi2g1v0119800 | 21 | ||
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|I1MNX4|I1MNX4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119800 | 20 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT1G48030.1 mitochondrial lipoamide dehydrogenase 1; Swiss-Prot: sp|P31023|DLDH_PEA Dihydrolipoyl dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A1J7G486|A0A1J7G486_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0334700 | 20 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.1 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.2 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 | ||
| – | Glutathione reductase; TAIR: AT3G54660.1 glutathione reductase; Swiss-Prot: sp|P27456|GSHRP_PEA Glutathione reductase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|V7BIC1|V7BIC1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0175100 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |