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IPR016156 is a FAD/NAD-linked reductase, dimerisation domain superfamily.
<p>This superfamily represents a dimerisation domain that is usually found at the C-terminal of FAD and NAD-linked reductases. This domain has a core α+β sandwich structure consisting of beta(3,4)-alpha(3). The first two domains are of the same β/β/α fold. This domain can be found in the following proteins:</p> <ul> <li>Glutathione reductase [[cite:PUB00024255]].</li> <li>Trypanothione reductase [[cite:PUB00020217]].</li> <li>Mammalian thioredoxin reductase [[cite:PUB00025549]].</li> <li>Apoptosis-inducing factor (AIF), which contains a large loop insertion in this domain [[cite:PUB00027231]].</li> <li>NADH peroxidase [[cite:PUB00037266]].</li> <li>Biphenyl 2,3-dioxygenase, ferredoxin reductase (also known as NADH-dependent ferredoxin reductase, BphA4) [[cite:PUB00024128]].</li> <li>Putidaredoxin reductase [[cite:PUB00030078]].</li> <li>Dihydrolipoyl dehydrogenase (also known as dihydrolipoamide dehydrogenase) [[cite:PUB00019486]].</li> <li>2-oxopropyl-CoM reductase, carboxylating (also known as NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase) [[cite:PUB00027392]].</li> <li>The flavin-binding subunit of flavocytochrome c sulphide dehydrogenase (FCSD) [[cite:PUB00035398]].</li> <li>NADH oxidase /nitrite reductase.</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydrolipoyl dehydrogenase, mitochondrial-like [Cicer arietinum] gi|502150750|ref|XP_004508105.1| | 18 | ||
| – | Dihydrolipoyl dehydrogenase [Medicago truncatula] gi|357478937|ref|XP_003609754.1| | 25 | ||
| – | PREDICTED: glutathione reductase, chloroplastic/mitochondrial-like isoform X1 [Cicer arietinum] gi|502115176|ref|XP_004495142.1| | 24 | ||
| – | Monodehydroascorbate reductase; TAIR: AT3G27820.1 monodehydroascorbate reductase 4; Swiss-Prot: sp|Q9LK94|MDAR4_ARATH Monodehydroascorbate reductase 4, peroxisomal; TrEMBL-Plants: tr|A0A072TXL0|A0A072TXL0_MEDTR Monodehydroascorbate reductase; Found in the gene: LotjaGi1g1v0608300 | 20 | ||
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|A0A151S7T2|A0A151S7T2_CAJCA Glutathione reductase, cytosolic; Found in the gene: LotjaGi2g1v0119800 | 21 | ||
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|A0A151S7T2|A0A151S7T2_CAJCA Glutathione reductase, cytosolic; Found in the gene: LotjaGi2g1v0119800 | 21 | ||
| – | Glutathione reductase; TAIR: AT3G24170.1 glutathione-disulfide reductase; Swiss-Prot: sp|Q43621|GSHRC_PEA Glutathione reductase, cytosolic; TrEMBL-Plants: tr|I1MNX4|I1MNX4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119800 | 20 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT1G48030.1 mitochondrial lipoamide dehydrogenase 1; Swiss-Prot: sp|P31023|DLDH_PEA Dihydrolipoyl dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A1J7G486|A0A1J7G486_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0334700 | 20 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.1 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 | ||
| – | Dihydrolipoyl dehydrogenase; TAIR: AT3G16950.2 lipoamide dehydrogenase 1; Swiss-Prot: sp|A8MS68|PLPD1_ARATH Dihydrolipoyl dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JMT6|G7JMT6_MEDTR Dihydrolipoamide dehydrogenase; Found in the gene: LotjaGi4g1v0335200 | 27 | ||
| – | Monodehydroascorbate reductase; TAIR: AT1G63940.2 monodehydroascorbate reductase 6; Swiss-Prot: sp|P92947|MDAR5_ARATH Monodehydroascorbate reductase 5, mitochondrial; TrEMBL-Plants: tr|A0A151SV13|A0A151SV13_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0429900 | 12 | ||
| – | Monodehydroascorbate reductase; TAIR: AT3G52880.1 monodehydroascorbate reductase 1; Swiss-Prot: sp|Q40977|MDAR_PEA Monodehydroascorbate reductase; TrEMBL-Plants: tr|A0A1J7G7M7|A0A1J7G7M7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0092900 | 12 | ||
| – | Glutathione reductase; TAIR: AT3G54660.1 glutathione reductase; Swiss-Prot: sp|P27456|GSHRP_PEA Glutathione reductase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|V7BIC1|V7BIC1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0175100 | 26 | ||
| – | Glutathione reductase; TAIR: AT3G54660.1 glutathione reductase; Swiss-Prot: sp|P27456|GSHRP_PEA Glutathione reductase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0B2P3G4|A0A0B2P3G4_GLYSO Glutathione reductase, chloroplastic; Found in the gene: LotjaGi5g1v0175100 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55424 | SUPERFAMILY | 1 | 7.14 |