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IPR006285 is a Ubiquitin-like modifier-activating enzyme Atg7.
<p>This is a family of eukaryotic proteins found in animals, plants, and yeasts that includes Atg7p (YHR171W) from Saccharomyces cerevisiae (Baker's yeast) and ATG7 from Pichia angusta. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity to ubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by ATG7 [[cite:PUB00066530]], and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family are involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.</p> <p>This protein is important for several processes. It plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration [[cite:PUB00095362]], the maintenance of hematopoietic stem cells [[cite:PUB00095361]], the formation of Paneth cell granules [[cite22291845]], as well as in adipose differentiation [[cite:PUB00095363]]. It is involved in circadian clock regulation in the liver and glucose metabolism through the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner [[cite:PUB00095360]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ubiquitin-like modifier-activating enzyme atg7-like [Glycine max] gi|363806674|ref|NP_001242518.1| | 10 | ||
| – | Ubiquitin-like modifier-activating enzyme atg7-like [Glycine max] gi|363806674|ref|NP_001242518.1| | 8 | ||
| – | Ubiquitin-like modifier-activating enzyme atg7; TAIR: AT5G45900.1 ThiF family protein; Swiss-Prot: sp|Q94CD5|ATG7_ARATH Ubiquitin-like modifier-activating enzyme atg7; TrEMBL-Plants: tr|A0A0B2RJ97|A0A0B2RJ97_GLYSO Ubiquitin-like modifier-activating enzyme atg7; Found in the gene: LotjaGi3g1v0547800 | 16 | ||
| – | Ubiquitin-like modifier-activating enzyme atg7; TAIR: AT5G45900.1 ThiF family protein; Swiss-Prot: sp|Q94CD5|ATG7_ARATH Ubiquitin-like modifier-activating enzyme atg7; TrEMBL-Plants: tr|A0A0B2RJ97|A0A0B2RJ97_GLYSO Ubiquitin-like modifier-activating enzyme atg7; Found in the gene: LotjaGi3g1v0547800 | 16 | ||
| – | Ubiquitin-like modifier-activating enzyme atg7; TAIR: AT5G45900.1 ThiF family protein; Swiss-Prot: sp|Q94CD5|ATG7_ARATH Ubiquitin-like modifier-activating enzyme atg7; TrEMBL-Plants: tr|A0A0B2RJ97|A0A0B2RJ97_GLYSO Ubiquitin-like modifier-activating enzyme atg7; Found in the gene: LotjaGi3g1v0547800 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01486 | CDD | 1 | 20.00 |