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IPR006353 is a HAD-superfamily hydrolase, subfamily IIA, CECR5.
<p>This family is a member of the Class IIA subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. Sequences in this family are all from eukaryotes. The human sequence is called "Cat Eye Syndrome critical region protein 5" (CECR5) [[cite:PUB00015450]], also known as Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5). The gene codifying for this protein has been cloned from a pericentromere region of human chromosome 22 believed to be the location of the gene or genes responsible for Cat Eye Syndrome. This is one of a number of candidate genes.</p> <p>The Schizosaccharomyces pombe (Fission yeast) sequence used to be annotated as "phosphatidyl synthase" due to a C-terminal region of the protein (outside the region of similarity covered by this entry) which is highly homologous to a family of CDP-alcohol phosphatidyltransferases. It is currently known as Cardiolipin synthase (CMP-forming) / mitochondrial hydrolase fusion protein as it is cleaved into two chains, one of which catalyses the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG) [[cite:PUB00151491]].</p> <p>This family also includes Mitochondrial hydrolase YKR070W from Saccharomyces cerevisiae [[cite:PUB00042821]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cat eye syndrome critical region protein [Medicago truncatula] gi|357453997|ref|XP_003597279.1| | 10 | ||
| – | Cat eye syndrome critical region protein [Medicago truncatula] gi|357453997|ref|XP_003597279.1| | 11 | ||
| – | Hydrolase family protein/HAD-superfamily protein; TAIR: AT3G45740.1 hydrolase family protein / HAD-superfamily protein; Swiss-Prot: sp|O13899|YF38_SCHPO Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c; TrEMBL-Plants: tr|A0A151SV01|A0A151SV01_CAJCA Uncharacterized protein YKR070W family; Found in the gene: LotjaGi3g1v0269400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01460 | TIGRFAM | 1 | 33.33 |