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IPR006370 is a 4-hydroxybenzoate polyprenyltransferase-like.
<p>Members of this family show a broad specificity for prenyl diphosphates, accepting substrates of different chain lengths. Genes coding for these enzymes have been identified in many organisms, and are mostly responsible for ubiquinone (UQ) biosynthesis [[cite:PUB00074584], [cite:PUB00074585], [cite:PUB00074586]]. 4-hydroxybenzoate solanesyltransferase from cyanobacteria displays a broad specificity with regard to the prenyl donor substrate and uses not only solanesyl diphosphate, but also a number of shorter-chain prenyl diphosphates [[cite:PUB00074587]]. One exception is LePGT1 (Lithospermum erythrorhizon 4-hydroxybenzoic acid geranyltransferase), which only accepts GPP (geranyl diphosphate) and is involved in the biosynthesis of a red naphthoquinone, shikonin, a plant secondary metabolite [[cite:PUB00074588]]. LePGT1 was reported to be the key regulatory enzyme of shikonin biosynthesis [[cite:PUB00074583]] and is not relevant to the formation of UQ [[cite:PUB00074582]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Para-hydroxybenzoate-polyprenyltransferase [Medicago truncatula] gi|357506705|ref|XP_003623641.1| | 15 | ||
| – | 4-hydroxybenzoate octaprenyltransferase; TAIR: AT4G23660.1 polyprenyltransferase 1; Swiss-Prot: sp|Q93YP7|COQ2_ARATH 4-hydroxybenzoate polyprenyltransferase, mitochondrial; TrEMBL-Plants: tr|G7KY71|G7KY71_MEDTR 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Found in the gene: LotjaGi1g1v0459100 | 17 | ||
| – | 4-hydroxybenzoate octaprenyltransferase; TAIR: AT4G23660.1 polyprenyltransferase 1; Swiss-Prot: sp|Q93YP7|COQ2_ARATH 4-hydroxybenzoate polyprenyltransferase, mitochondrial; TrEMBL-Plants: tr|M5WWI9|M5WWI9_PRUPE 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Found in the gene: LotjaGi1g1v0459100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd13959 | CDD | 1 | 33.33 |