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IPR006642 is a Rad18, zinc finger UBZ4-type.
<p>The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [[cite:PUB00094761], [cite:PUB00091153]]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [[cite:PUB00094763], [cite:PUB00091660], [cite:PUB00094767]], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [[cite:PUB00094758], [cite:PUB00094765]], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [[cite:PUB00041615], [cite:PUB00094762], [cite:PUB00094764]], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [[cite:PUB00094766], [cite:PUB00094760], [cite:PUB00094768]].</p> <p>This entry represents type 4 UBZ found in RAD18. The domain is a potential zinc finger for nucleic acid binding and a putative nucleotide binding sequence [[cite:PUB00009702]]. Human RAD18 accumulates very rapidly and remains for a long period of time at sites of different types of DNA damage, and is required of DNA. RAD18 appears to respond to DNA damage in two distinct ways: replication-dependent and replication-independent. The RAD18-type zinc finger located in the middle of RAD18 is responsible for the replication-independent accumulation of RAD18 following DNA damage, while a second zinc finger, SAP-type, is responsible for replication-dependent accumulation [[cite:PUB00035841]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein isoform 1 [Theobroma cacao] gi|508701081|gb|EOX92977.1| | 4 | ||
| – | Protein hapless 8; TAIR: AT5G56250.1 hapless 8; Swiss-Prot: sp|Q9UBT6|POLK_HUMAN DNA polymerase kappa; TrEMBL-Plants: tr|K7M4L6|K7M4L6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0040000 | 6 | ||
| – | Fanconi-associated nuclease 1 like; TAIR: AT1G48360.2 zinc ion binding/nucleic acid binding/hydrolase; Swiss-Prot: sp|Q5XVJ4|FAN1_ARATH Fanconi-associated nuclease 1 homolog; TrEMBL-Plants: tr|G7KUQ4|G7KUQ4_MEDTR Fanconi-associated nuclease-like protein; Found in the gene: LotjaGi1g1v0531200 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |