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IPR006735

Source: InterPro

Description

IPR006735 is a Replication termination factor 2.

<p>This entry represents Replication termination factor 2 from Schizosaccharomyces pombe (Rtf2) and similar eukaryotic proteins [[cite:PUB00066779]].</p> <p>The site-specific replication barrier RTS1 terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 was thought to stabilise the replication fork stalled at the RTS1 element by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin [[cite:PUB00066779]]. However, this protein has been later reported to be associated with mRNA processing and splicing factors, and essential for the correct splicing of the rtf1 transcript, necessary for a functional Rtf1 protein (Replication Termination Factor 1) and thus for RTS activity [[cite:PUB00153784]]. Its human homologue has been reported essential for the ability of cells to manage replication stress [[cite:PUB00153785], [cite:PUB00153786]]</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:1902979
Biological process Mitotic DNA replication termination Any DNA replication termination involved in mitotic cell cycle DNA replication.
Subterm of
Part of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0256049.1
– PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1|
Domains
4
Lj0g3v0256049.2
– PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1|
Domains
5
Lj0g3v0256059.1
– PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1|
Domains
4
Lj0g3v0342989.1
– PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1|
Domains
8
Lj5g3v0626900.1
– PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1|
Domains
6
LotjaGi4g1v0286400.1
– Protein RTF2-like protein; TAIR: AT5G58020.1 RTF2 RING-finger protein; Swiss-Prot: sp|A5GFW7|RTF2_PIG Protein RTF2 homolog; TrEMBL-Plants: tr|I3SA36|I3SA36_MEDTR Uncharacterized protein; Found in the gene: LotjaGi4g1v0286400
Domains
11
LotjaGi5g1v0077500_LC.1
– Protein RTF2-like protein; TAIR: AT5G58020.1 RTF2 RING-finger protein; Swiss-Prot: sp|Q0VCR1|RTF2_BOVIN Protein RTF2 homolog; TrEMBL-Plants: tr|G7JGT3|G7JGT3_MEDTR Replication termination factor 2; Found in the gene: LotjaGi5g1v0077500_LC
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 14.29