Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027799 is a Replication termination factor 2, RING-finger.
<p>This entry represents the RING-finger domain of Replication termination factor 2 from Schizosaccharomyces pombe (Rtf2) and similar eukaryotic proteins. This RING finger-like structure forms only one functional Zn2+ ion-binding site [[cite:PUB00066779]].</p> <p>The site-specific replication barrier RTS1 terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 was thought to stabilise the replication fork stalled at the RTS1 element by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin [[cite:PUB00066779]]. However, this protein has been later reported to be associated with mRNA processing and splicing factors, and essential for the correct splicing of the rtf1 transcript, necessary for a functional Rtf1 protein (Replication Termination Factor 1) and thus for RTS activity [[cite:PUB00153784]]. Its human homologue has been reported essential for the ability of cells to manage replication stress [[cite:PUB00153785], [cite:PUB00153786]]</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein TCM_037082 [Theobroma cacao] gi|508782327|gb|EOY29583.1| | 2 | ||
| – | PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1| | 4 | ||
| – | PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1| | 5 | ||
| – | PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1| | 4 | ||
| – | PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1| | 8 | ||
| – | Peptidyl-prolyl cis-trans isomerase-like protein [Medicago truncatula] gi|357482585|ref|XP_003611579.1| | 9 | ||
| – | PREDICTED: protein RTF2 homolog [Cicer arietinum] gi|502149950|ref|XP_004507721.1| | 6 | ||
| – | Protein RTF2-like protein; TAIR: AT5G58020.1 RTF2 RING-finger protein; Swiss-Prot: sp|A5GFW7|RTF2_PIG Protein RTF2 homolog; TrEMBL-Plants: tr|I3SA36|I3SA36_MEDTR Uncharacterized protein; Found in the gene: LotjaGi4g1v0286400 | 11 | ||
| – | Protein RTF2-like protein; TAIR: AT5G58020.1 RTF2 RING-finger protein; Swiss-Prot: sp|Q0VCR1|RTF2_BOVIN Protein RTF2 homolog; TrEMBL-Plants: tr|G7JGT3|G7JGT3_MEDTR Replication termination factor 2; Found in the gene: LotjaGi5g1v0077500_LC | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |