Description

IPR006775 is a Glycosyl-hydrolase family 116, catalytic region.

<p>This entry represents the catalytic region found in the CAZyme GH116 family members, which presently includes enzymes with beta-glucosidase ([ec:3.2.1.21]), beta-xylosidase ([ec:3.2.1.37]) , and glucocerebrosidase ([ec:3.2.1.45]) activity [[cite:PUB00073615]]. Proteins containing this domain include animal non-lysosomal glucosylceramidase GBA2, which catalyse the conversion of glucosylceramide to free glucose and ceramide [[cite:PUB00044658]]. GBA2 is involved in sphingomyelin generation and prevention of glycolipid accumulation and may also catalyse the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo [[cite:PUB00044659]]. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia [[cite:PUB00078737]]. The catalytic nucleophile, identified in [swissprot:Q97YG8] is a glutamine-335, with the likely acid/base at Asp-442 and the aspartates at Asp-406 and Asp-458 residues also playing a role in the catalysis of glucosides and xylosides that are beta-bound to hydrophobic groups [[cite:PUB00073615]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: