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IPR024462 is a Glycosyl-hydrolase family 116, N-terminal.
<p>This entry represents the N-terminal domain found in the CAZyme GH116 family members, which presently includes enzymes with beta-glucosidase ([ec:3.2.1.21]), beta-xylosidase ([ec:3.2.1.37]) , and glucocerebrosidase ([ec:3.2.1.45]) activity [[cite:PUB00078737], [cite:PUB00073615]]. The N-terminal is thought to be the luminal domain while the C-terminal is the cytosolic domain.</p> <p>Proteins containing this domain include animal non-lysosomal glucosylceramidase GBA2, which catalyse the conversion of glucosylceramide to free glucose and ceramide [[cite:PUB00044658]]. GBA2 is involved in sphingomyelin generation and prevention of glycolipid accumulation and may also catalyse the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo [[cite:PUB00044659]]. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia [[cite:PUB00078737]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: non-lysosomal glucosylceramidase-like isoform X1 [Cicer arietinum] gi|502126614|ref|XP_004499373.1| | 14 | ||
| – | PREDICTED: non-lysosomal glucosylceramidase-like isoform X1 [Cicer arietinum] gi|502126614|ref|XP_004499373.1| | 4 | ||
| – | Non-lysosomal glucosylceramidase [Medicago truncatula] gi|357440847|ref|XP_003590701.1| | 12 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT5G49900.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A072UUL4|A0A072UUL4_MEDTR Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi4g1v0001000 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT5G49900.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A072UUL4|A0A072UUL4_MEDTR Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi4g1v0001000 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT5G49900.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A072UUL4|A0A072UUL4_MEDTR Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi4g1v0001000 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A151T106|A0A151T106_CAJCA Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 10 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q9HCG7|GBA2_HUMAN Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|G7I2L4|G7I2L4_MEDTR Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 5 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A0S3SPA3|A0A0S3SPA3_PHAAN Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A072VX24|A0A072VX24_MEDTR Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A151T106|A0A151T106_CAJCA Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 11 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A0S3SPA3|A0A0S3SPA3_PHAAN Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 12 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A0S3SPA3|A0A0S3SPA3_PHAAN Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 14 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A0S3SPA3|A0A0S3SPA3_PHAAN Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A0S3SPA3|A0A0S3SPA3_PHAAN Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 13 | ||
| – | Non-lysosomal glucosylceramidase; TAIR: AT3G24180.1 Beta-glucosidase, GBA2 type family protein; Swiss-Prot: sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase; TrEMBL-Plants: tr|A0A151T106|A0A151T106_CAJCA Non-lysosomal glucosylceramidase; Found in the gene: LotjaGi5g1v0163400 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48208 | SUPERFAMILY | 1 | 6.25 |