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IPR006809

Source: InterPro

Description

IPR006809 is a TAFII28-like protein domain.

<p>The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. This entry represents a conserved domain found at the C terminus of Transcription initiation factor TFIID subunit 11 from humans (also known as Transcription initiation factor TFIID 28 kDa subunit, TAFII28 [[cite:PUB00014354]]). TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone [[cite:PUB00101136]]. It also interacts directly with TFIIA, acting as a bridging factor that stabilises the TFIIA-TBP-DNA complex [[cite:PUB00101135]]. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four α-helices and three loops arranged as in histone H3 [[cite:PUB00008579], [cite:PUB00006419]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005634
Cellular component Nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Subterm of
GO:0006367
Biological process Transcription initiation from RNA polymerase II promoter Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
Subterm of
Part of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0296239.1
– PREDICTED: transcription initiation factor TFIID subunit 11-like isoform X2 [Cicer arietinum] gi|502174102|ref|XP_004515436.1|
Domains
8
Lj1g3v2534840.1
– PREDICTED: transcription initiation factor TFIID subunit 11-like isoform X2 [Cicer arietinum] gi|502174102|ref|XP_004515436.1|
Domains
7
LotjaGi3g1v0051800.3
– Transcription initiation factor TFIID subunit 11; TAIR: AT4G20280.1 TBP-associated factor 11; Swiss-Prot: sp|Q9M565|TAF11_ARATH Transcription initiation factor TFIID subunit 11; TrEMBL-Plants: tr|I3SI80|I3SI80_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0051800
Domains
14
LotjaGi4g1v0237700.1
– Transcription initiation factor TFIID subunit 11; TAIR: AT4G20280.1 TBP-associated factor 11; Swiss-Prot: sp|Q9M565|TAF11_ARATH Transcription initiation factor TFIID subunit 11; TrEMBL-Plants: tr|I3SI80|I3SI80_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0237700
Domains
9
LotjaGi4g1v0237700.2
– Transcription initiation factor TFIID subunit 11; TAIR: AT4G20280.1 TBP-associated factor 11; Swiss-Prot: sp|Q9M565|TAF11_ARATH Transcription initiation factor TFIID subunit 11; TrEMBL-Plants: tr|I3SI80|I3SI80_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0237700
Domains
9
LotjaGi4g1v0237700.3
– Transcription initiation factor TFIID subunit 11; TAIR: AT4G20280.1 TBP-associated factor 11; Swiss-Prot: sp|Q9M565|TAF11_ARATH Transcription initiation factor TFIID subunit 11; TrEMBL-Plants: tr|I3SI80|I3SI80_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0237700
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67